Transcription Factor

Accessions: Q04743 (JASPAR 2024)
Names: Empty spiracles homolog 2, Empty spiracles-like protein 2, EMX2_HUMAN, Homeobox protein EMX2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q04743
Length: 252
Pfam Domains: 155-211 Homeobox domain
Sequence:
(in bold interface residues)
1 MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAG 60
61 RGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPSSHSPHPLFASQQRDPSTFY 120
121 PWLIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRTAFSPSQLLRLEHAFEKNHYVV 180
181 GAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEEGSDSQQKKKGTHHINRWRIATKQ 240
241 ASPEEIDVTSDD
Interface Residues: 152, 155, 156, 157, 158, 196, 197, 199, 200, 203, 204, 207, 208, 211
3D-footprint Homologues: 1ig7_A, 1fjl_B, 5zfz_A, 2h1k_B, 1puf_A, 3cmy_A, 6a8r_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 7q3o_C, 6es3_K, 2ld5_A, 5jlw_D, 4cyc_A, 1b72_A, 4xrs_G, 3a01_E, 5flv_I, 5zjt_E, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 2hos_A, 2xsd_C, 1le8_A, 7xrc_C, 4j19_B, 1e3o_C, 1au7_A, 3l1p_A, 1o4x_A, 1le8_B, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 4xrm_B
Binding Motifs: MA0886.1 rsTAATTAgs
MA0886.2 TAATTA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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