Transcription Factor

						

			
Accessions: A6NLW8 (JASPAR 2024)

			
Names: DUXA_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: A6NLW8
Length: 204
Pfam Domains:     16-70 Homeobox domain
    37-69 Homeobox KN domain
  102-155 Homeobox domain
  121-155 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MAEDTYSHKMVKTNHRRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQ   60
  61 IWFQNRRARHGFQKRPEAETLESSQSQGQDQPGVEFQSREARRCRTTYSASQLHTLIKAF  120
 121 MKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRLLLQRKREPVASLEQEEQGKIPEGL  180
 181 QGAEDTQNGTNFTSDSHFSGARTW
Interface Residues: 16, 19, 61, 64, 65, 68, 75, 102, 103, 104, 105, 141, 142, 143, 144, 146, 147, 150, 151, 154, 155
3D-footprint Homologues: 5zfz_A, 6m3d_C, 1ig7_A, 6a8r_A, 3d1n_M, 2h1k_B, 1puf_A, 1fjl_B, 3cmy_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 5jlw_D, 4cyc_A, 5flv_I, 3l1p_A, 3a01_E, 1au7_A, 5zjt_E, 5gpc_B, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 1du0_A, 1o4x_A, 4qtr_D, 1k61_B, 8g87_X, 4xrm_B
Binding Motifs: MA0884.1 ytrAyytAATCAr
MA0884.2 yTrAyTwArTyAr
			
Publications: Young JM, Whiddon JL, Yao Z, Kasinathan B, Snider L, Geng LN, Balog J, Tawil R, van der Maarel SM, Tapscott SJ. DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis. PLoS Genet : (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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