Transcription Factor
| Accessions: | T049527_1.02 (CISBP 1.02), O35738 (JASPAR 2024) |
| Names: | Klf12, T049527_1.02;, KLF12_MOUSE, Krueppel-like factor 12, Transcriptional repressor AP-2rep |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 402 |
| Pfam Domains: | 317-341 Zinc finger, C2H2 type 317-341 C2H2-type zinc finger 333-350 Zinc-finger double domain 347-371 C2H2-type zinc finger 347-371 Zinc finger, C2H2 type 364-388 Zinc-finger double domain 377-399 C2H2-type zinc finger 377-399 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MNIHMKRKTIKNLSALENRMLMLDGMPAVRVKTELVESEQGSPNVHNYPDMEAVPLLLNN 60 61 VKGEPPEDSLPVDHFQTQTEPVDLSINKARTSPTAASSSPVSMTASASSPSSTSTSSSSS 120 121 SRPASSPTVITSVSSASSSSTVLSPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKL 180 181 SHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRSHGKAQMEPRGLSPRQSKSDS 240 241 DDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFACSISPFSIEST 300 301 RRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFAR 360 361 SDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV |
| Interface Residues: | 302, 306, 329, 330, 331, 332, 333, 335, 336, 338, 339, 342, 359, 360, 361, 362, 363, 365, 366, 367, 370, 387, 388, 389, 390, 391, 392, 393, 394, 395, 398 |
| 3D-footprint Homologues: | 5kkq_D, 6jnm_A, 3uk3_C, 8cuc_F, 1tf3_A, 6ml4_A, 7n5w_A, 1ubd_C, 7ysf_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 5v3j_F, 2gli_A, 1g2f_F, 6blw_A, 1tf6_A, 6u9q_A, 2i13_A, 5kl3_A, 8h9h_G, 2lt7_A, 7y3m_I, 6e94_A, 6a57_A, 2jpa_A, 7y3l_A, 4m9v_C, 2wbs_A, 2drp_D, 1f2i_J, 8gn3_A, 5yel_A, 4x9j_A, 1llm_D, 7txc_E, 5yj3_D |
| Binding Motifs: | MA0742.1 GrCCACGCCCwthtw M0443_1.02 wGGGyGkggy |
| Publications: | Lomberk G, Urrutia R. The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J : (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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