Transcription Factor

Accessions: Q6NT76 (JASPAR 2024)
Names: HMBX1_HUMAN, Homeobox telomere-binding protein 1, Homeobox-containing protein 1, Telomere-associated homeobox-containing protein 1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 420
Pfam Domains: 25-228 Hepatocyte nuclear factor 1 (HNF-1), N terminus
269-339 Homeobox domain
Sequence:
(in bold interface residues)
1 MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK 60
61 FGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRE 120
121 NNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAF 180
181 LANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRP 240
241 APIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEI 300
301 ANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGG 360
361 HSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD 420
Interface Residues: 188, 198, 199, 200, 201, 203, 204, 211, 212, 267, 268, 270, 271, 327, 328, 331, 332, 335, 336, 339
3D-footprint Homologues: 2r1j_L, 1ic8_B, 2h8r_B, 4j19_B, 1mnm_C, 3cmy_A, 1fjl_B, 1k61_B, 1puf_B, 1le8_A, 1ig7_A, 2hdd_A, 3a01_E, 1b72_A, 4xrm_B, 1du0_A, 2lkx_A, 3lnq_A, 2hos_A
Binding Motifs: MA0895.1 myTAGTTAms
MA0895.2 TAGTTAm
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.