Transcription Factor
| Accessions: | P73_HUMAN (HOCOMOCO 10), O15350 (JASPAR 2024) |
| Names: | p53-like transcription factor, p53-related protein, P73_HUMAN, Tumor protein p73 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 636 |
| Pfam Domains: | 114-309 P53 DNA-binding domain 345-384 P53 tetramerisation motif 486-549 SAM domain (Sterile alpha motif) |
| Sequence: (in bold interface residues) | 1 MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS 60 61 VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD 120 121 YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPV 180 181 YKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY 240 241 EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGR 300 301 DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVR 360 361 GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGG 420 421 MNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSH 480 481 CTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT 540 541 IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRG 600 601 GPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH |
| Interface Residues: | 138, 139, 268, 296, 297, 300, 301 |
| 3D-footprint Homologues: | 7xzx_N, 3q05_B, 7xzz_N, 5kbd_B, 3exj_A, 3qyn_C |
| Binding Motifs: | MA0861.1 drCATGTcyrrACAyGym P73_HUMAN.H10MO.A|M01415 rgrCAwGyytGgrCwTGyyy MA0861.2 rCATGTcyrrACAyGy |
| Publications: | Ethayathulla AS, Nguyen HT, Viadiu H. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements. J Biol Chem 288:4744-54 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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