Transcription Factor
| Accessions: | P42586 (JASPAR 2024) |
| Names: | Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2, NKX22_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 273 |
| Pfam Domains: | 129-185 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSLTNTKTGFSVKDILDLPDTNDEDGSVAEGPEEESEGPEPAKRAGPLGQGALDAVQSLP 60 61 LKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETQG 120 121 GGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHR 180 181 YKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQ 240 241 SLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW |
| Interface Residues: | 78, 79, 85, 89, 128, 129, 130, 131, 132, 170, 171, 173, 174, 177, 178, 181, 182, 185 |
| 3D-footprint Homologues: | 3l1p_A, 4j19_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 6a8r_A, 3cmy_A, 1puf_A, 1fjl_B, 1zq3_P, 1nk2_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hos_A, 1au7_A, 4cyc_A, 6m3d_C, 5flv_I, 1b72_A, 5zjt_E, 3a01_E, 1jgg_B, 7psx_B, 3lnq_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 1le8_A, 7xrc_C, 2xsd_C, 8g87_X, 5hod_A, 1o4x_A, 1du0_A, 4qtr_D, 1k61_B |
| Binding Motifs: | PH0111.1 hwarCCACTTGArawtw |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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