Transcription Factor
| Accessions: | KLF14 (humanC2H2ZF-ChIP Feb2015), Q8TD94 (JASPAR 2024) |
| Names: | ENSG00000174595, KLF14, Q8TD94, Basic transcription element-binding protein 5, BTE-binding protein 5, KLF14_HUMAN, Krueppel-like factor 14, Transcription factor BTEB5 |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8TD94 |
| Notes: | TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 323 |
| Pfam Domains: | 195-219 Zinc finger, C2H2 type 211-238 Zinc-finger double domain 225-249 C2H2-type zinc finger 225-249 Zinc finger, C2H2 type 242-266 Zinc-finger double domain 255-277 C2H2-type zinc finger 255-277 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MSAAVACLDYFAAECLVSMSAGAVVHRRPPDPEGAGGAAGSEVGAAHPESALPGPGPSGP 60 61 ASVPQLPQVPAPSPGAGGAAPHLLAASVWADLRGSSGEGSWENSGEAPRASSGFSDPIPC 120 121 SVQTPCSELAPASGAAAVCAPESSSDAPAVPSAPAAPGAPAASGGFSGGALGAGPAPAAD 180 181 QAPRRRSVTPAAKRHQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSD 240 241 ELARHYRTHTGEKRFSCPLCPKQFSRSDHLTKHARRHPTYHPDMIEYRGRRRTPRIDPPL 300 301 TSEVESSASGSGPGPAPSFTTCL |
| Interface Residues: | 185, 207, 208, 209, 210, 211, 213, 214, 216, 217, 220, 236, 237, 238, 239, 240, 241, 243, 244, 245, 248, 265, 266, 267, 268, 269, 270, 271, 272, 273, 275, 276, 292, 295, 296, 297, 298 |
| 3D-footprint Homologues: | 1ubd_C, 7y3l_A, 7n5w_A, 1tf3_A, 6jnm_A, 8cuc_F, 1g2f_F, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 2i13_A, 6blw_A, 5kkq_D, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 7ysf_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 7eyi_G, 8h9h_G, 2lt7_A, 7y3m_I, 6wmi_A, 6a57_A, 2jpa_A, 6e94_A, 5k5i_A, 8gn3_A, 3uk3_C, 1llm_D, 2wbs_A, 5yel_A, 7txc_E, 2drp_D, 1f2i_J, 4m9v_C, 5k5l_F, 5v3j_F, 5yj3_D |
| Binding Motifs: | MA0740.1 krcCACGCCCmYyt KLF14_ChIP wGGGyGkGG MA0740.2 kGGGCGKGG |
| Publications: | Lomberk G, Urrutia R. The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J : (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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