Transcription Factor
| Accessions: | pho (DrosophilaTF 1.1), T057675_1.02 (CISBP 1.02), Q8ST83 (JASPAR 2024) |
| Names: | PHO_DROME, Polycomb protein PHO, Protein pleiohomeotic, Transcription factor YY1 homolog, pho, T057675_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8ST83 |
| Notes: | experiment type:B1H, family:C2H2 ZF |
| Length: | 520 |
| Pfam Domains: | 358-381 C2H2-type zinc finger 386-408 C2H2-type zinc finger 386-408 Zinc finger, C2H2 type 401-426 Zinc-finger double domain 414-438 C2H2-type zinc finger 414-438 Zinc finger, C2H2 type 430-456 Zinc-finger double domain 444-468 Zinc finger, C2H2 type 444-468 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYN 60 61 IHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTE 120 121 ESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSD 180 181 QIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKER 240 241 GNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDL 300 301 HALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACP 360 361 HKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEG 420 421 CGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGK 480 481 SGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD |
| Interface Residues: | 341, 342, 343, 346, 369, 370, 371, 372, 373, 375, 376, 377, 378, 379, 396, 397, 398, 399, 400, 401, 402, 403, 404, 426, 427, 428, 429, 430, 432, 433, 456, 457, 458, 459, 460, 461, 462, 463, 467 |
| 3D-footprint Homologues: | 5v3j_F, 2i13_A, 1tf6_A, 7w1m_H, 2lt7_A, 6wmi_A, 5ei9_F, 8ssq_A, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 5yel_A, 7eyi_G, 4m9v_C, 7ysf_A, 2jpa_A, 1ubd_C, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 1tf3_A, 4x9j_A, 1g2f_F, 7txc_E, 5kl3_A, 5und_A, 5k5i_A, 2kmk_A, 1mey_C, 2gli_A, 6blw_A, 8h9h_G, 6e94_A, 6a57_A, 3uk3_C, 2wbs_A, 5yj3_D, 1llm_D, 1f2i_J, 6u9q_A, 7y3m_I |
| Binding Motifs: | pho GCCATT M5151_1.02 rscgTtATGGCttm MA1460.1 mrATGGCCGmc MA1460.2 ATGGCCG |
| Binding Sites: | MA1460.1.1 MA1460.1.10 MA1460.1.11 MA1460.1.12 MA1460.1.13 MA1460.1.14 MA1460.1.15 MA1460.1.16 MA1460.1.17 MA1460.1.18 MA1460.1.19 MA1460.1.2 MA1460.1.20 MA1460.1.3 MA1460.1.4 MA1460.1.5 MA1460.1.6 MA1460.1.7 MA1460.1.8 MA1460.1.9 MA1460.2.3 MA1460.2.1 MA1460.2.10 / MA1460.2.11 / MA1460.2.12 / MA1460.2.5 / MA1460.2.7 / MA1460.2.9 MA1460.2.13 / MA1460.2.14 / MA1460.2.17 / MA1460.2.18 / MA1460.2.19 / MA1460.2.4 MA1460.2.15 MA1460.2.16 MA1460.2.2 / MA1460.2.8 MA1460.2.20 MA1460.2.6 |
| Publications: | Shimell M.J, Peterson A.J, Burr J, Simon J.A, O'Connor M.B. Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Developmental biology 218:38-52 (2000). [Pubmed] Enuameh MS et al (2013) Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Genome Res. 23(6):928-40. doi: 10.1101/gr.151472.112 [Pubmed] |
| Related annotations: | PaperBLAST |
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