Transcription Factor
| Accessions: | P19622 (JASPAR 2024) |
| Names: | HME2_HUMAN, Homeobox protein en-2, Homeobox protein engrailed-2, Hu-En-2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P19622 |
| Length: | 333 |
| Pfam Domains: | 245-301 Homeobox domain 302-333 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNH 60 61 QHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQ 120 121 LLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGS 180 181 LKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNP 240 241 NKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIK 300 301 KATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE |
| Interface Residues: | 239, 244, 245, 246, 247, 248, 286, 287, 289, 290, 293, 294, 297, 298, 301 |
| 3D-footprint Homologues: | 3a01_E, 3d1n_M, 1nk2_P, 1fjl_B, 5zfz_A, 6fqp_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 2ld5_A, 6es3_K, 4xrs_G, 2hos_A, 7psx_B, 4j19_B, 1b72_A, 5flv_I, 7q3o_C, 5zjt_E, 5hod_A, 3rkq_B, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 1puf_B, 1au7_A, 2xsd_C, 1le8_A, 7xrc_C, 1e3o_C, 1k61_B, 1o4x_A, 4qtr_D, 1le8_B, 6fqq_E, 1du0_A, 4xrm_B, 1mnm_C, 8g87_X |
| Binding Motifs: | MA0642.1 ssyAATTAss MA0642.2 msyAATTA MA0642.3 syAATTA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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