Transcription Factor
| Accessions: | ERG_MOUSE (HOCOMOCO 10), P81270 (JASPAR 2024) |
| Names: | ERG_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 486 |
| Pfam Domains: | 122-204 Sterile alpha motif (SAM)/Pointed domain 317-399 Ets-domain |
| Sequence: (in bold interface residues) | 1 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 60 61 QDWLSQAPARVTIKMECNPSQVNGSRNSPDECSVNKGGKMVGSPDTVGMSYGSYMEEKHV 120 121 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLFQNIDGKELCKMTK 180 181 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 240 241 TSVYPEATQRITTRPDLPYEPPRRSAWTGHSHLTPQSKAAQPSPSAVPKTEDQRPQLDPY 300 301 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGE 360 361 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS 420 421 DLPYMGSYHAHPQKMNFVSPHPPALPVTSSSFFASPNPYWNSPTGGIYPNTRLPASHMPS 480 481 HLGTYY |
| Interface Residues: | 94, 101, 114, 116, 117, 315, 370, 371, 373, 374, 375, 377, 378, 392 |
| 3D-footprint Homologues: | 1j4w_A, 3zp5_A, 4mhg_A, 2stt_A, 1dux_F, 4uno_A, 3jtg_A, 7jsa_J, 8ee9_F, 1bc8_C, 4iri_A, 4l18_B, 1awc_A, 4lg0_B, 1yo5_C, 4bqa_A |
| Binding Motifs: | MA0474.1 rsAGGAAGtrr ERG_MOUSE.H10MO.A|M01074 ACCGGAArTsm MA0474.3 rraCAGGAAGTgrs MA0474.4 aCAGGAAGTg |
| Binding Sites: | MA0474.4.3 MA0474.4.8 MA0474.1.1 MA0474.1.10 MA0474.1.11 MA0474.1.12 MA0474.1.13 MA0474.1.14 MA0474.1.15 MA0474.1.16 MA0474.1.17 MA0474.1.18 MA0474.1.19 MA0474.1.2 MA0474.1.20 MA0474.1.3 MA0474.1.4 MA0474.1.5 MA0474.1.6 MA0474.1.7 MA0474.1.8 MA0474.1.9 MA0474.4.16 MA0474.4.9 MA0474.3.1 MA0474.3.10 / MA0474.3.18 MA0474.3.11 / MA0474.3.19 MA0474.3.12 / MA0474.3.20 MA0474.3.13 MA0474.3.14 MA0474.3.15 MA0474.3.16 MA0474.3.17 MA0474.3.18 MA0474.3.19 MA0474.3.2 MA0474.3.20 MA0474.3.3 / MA0474.3.5 MA0474.3.4 / MA0474.3.6 MA0474.3.10 / MA0474.3.5 MA0474.3.11 / MA0474.3.6 MA0474.3.12 / MA0474.3.7 MA0474.3.16 / MA0474.3.8 MA0474.3.17 / MA0474.3.9 MA0474.4.4 MA0474.3.13 MA0474.3.14 MA0474.3.15 MA0474.3.3 MA0474.3.4 MA0474.3.7 MA0474.3.8 MA0474.3.9 MA0474.4.1 MA0474.4.10 MA0474.4.11 MA0474.4.12 MA0474.4.13 MA0474.4.14 MA0474.4.15 MA0474.4.17 MA0474.4.18 MA0474.4.19 MA0474.4.2 MA0474.4.20 MA0474.4.5 MA0474.4.6 MA0474.4.7 |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde M.M, Ismail M.A, Kumar A, Farahat A.A, Stephens C.E, Duterque-Coquillaud M, David Wilson W, Boykin D.W, David-Cordonnier M.H. Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic acids research 41:125-38 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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