Transcription Factor
| Accessions: | GCR_HUMAN (HOCOMOCO 10), P04150 (JASPAR 2024) |
| Names: | GCR_HUMAN, Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1 |
| Organisms: | Homo sapiens, Mus musculus, Rattus norvegicus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 777 |
| Pfam Domains: | 26-401 Glucocorticoid receptor 420-487 Zinc finger, C4 type (two domains) 548-735 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR 60 61 LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK 120 121 LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN 180 181 VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN 240 241 SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV 300 301 YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG 360 361 SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL 420 421 CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK 480 481 CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE 540 541 PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW 600 601 MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY 660 661 EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK 720 721 LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK |
| Interface Residues: | 429, 430, 432, 433, 439, 440, 442, 443, 446, 447, 471, 495, 497, 500, 501, 503, 515 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 1a6y_A, 3g9m_B, 1lo1_A, 4oln_B, 2a66_A, 8hbm_B, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 3cbb_A, 7xv6_B, 2han_A, 1hcq_E, 4umm_E, 8cef_H, 4iqr_B, 2han_B, 1kb2_B, 5cbx_B, 3g6t_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 1r4i_A, 5emc_A, 7prw_B, 3f2b_A |
| Binding Motifs: | MA0113.1 rrrAacAtwmyGTyCtrw MA0113.3 rrGwACAywrTGTwCym GCR_HUMAN.H10MO.A|M01184 rGrACAkksTGTyCy MA0113.2 rGaACAvaaTGThCy MA0113.4 rGwACAywrTGTwCy |
| Binding Sites: | MA0113.1.1 MA0113.1.2 MA0113.1.3 MA0113.1.4 MA0113.1.5 MA0113.1.6 MA0113.1.7 MA0113.1.8 MA0113.1.9 MA0113.2.1 MA0113.2.10 MA0113.2.11 MA0113.2.12 MA0113.2.13 MA0113.2.14 MA0113.2.15 MA0113.2.16 MA0113.2.17 MA0113.2.18 MA0113.2.19 MA0113.2.2 MA0113.2.20 MA0113.2.3 MA0113.2.4 MA0113.2.5 MA0113.2.6 MA0113.2.7 MA0113.2.8 MA0113.2.9 |
| Publications: | Sandelin A, Wasserman W.W. Prediction of nuclear hormone receptor response elements. Molecular endocrinology (Baltimore, Md.) 19:595-606 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.