Transcription Factor

Accessions: P10734 (JASPAR 2024)
Names: KNIR_DROME, Nuclear receptor subfamily 0 group A member 1, Zygotic gap protein knirps
Organisms: Drosophila melanogaster
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 429
Pfam Domains: 3-73 Zinc finger, C4 type (two domains)
Sequence:
(in bold interface residues)
1 MNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNISTISECKNEGKCIIDKKNRTTCKA 60
61 CRLRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSAS 120
121 SPVGSPHTPGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGG 180
181 VPHQSPFQLPPHLLFPGYHASAAAAAASAADAAYRQEMYKHRQSVDSVESQNRFSPASQP 240
241 PVVQPTSSARQSPIDVCLEEDVHSVHSHQSSASLLHPIAIRATPTTPTSSSPLSFAAKMQ 300
301 SLSPVSVCSIGGETTSVVPVHPPTVSAQEGPMDLSMKTSRSSVHSFNDSGSEDQEVEVAP 360
361 RRKFYQLEAECLTTSSSSSSHSAAHSPNTTTAHAEVKRQKLGGAEATHFGGFAVAHNAAS 420
421 AMRGIFVCV
Interface Residues: 13, 14, 16, 17, 23, 24, 26, 27, 30, 31, 56, 78, 81
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: MA0451.1 AAwcTAGrGCAs
MA0451.2 AAwcTAGrGCA
Binding Sites: MA0451.1.1
MA0451.1.10
MA0451.1.11
MA0451.1.12
MA0451.1.13
MA0451.1.14
MA0451.1.15
MA0451.1.16
MA0451.1.17
MA0451.1.18
MA0451.1.19
MA0451.1.2
MA0451.1.20
MA0451.1.3
MA0451.1.4
MA0451.1.5
MA0451.1.6
MA0451.1.7
MA0451.1.8
MA0451.1.9
MA0451.2.1 / MA0451.2.3
MA0451.2.10
MA0451.2.11
MA0451.2.12
MA0451.2.13
MA0451.2.14
MA0451.2.15
MA0451.2.16 / MA0451.2.19
MA0451.2.17
MA0451.2.18
MA0451.2.2 / MA0451.2.6
MA0451.2.20
MA0451.2.4
MA0451.2.5
MA0451.2.7
MA0451.2.8
MA0451.2.9
Publications: Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed]
Related annotations: PaperBLAST

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