Transcription Factor
| Accessions: | FEV_DBD (HumanTF 1.0), FEV (HT-SELEX2 May2017) |
| Names: | FEV, FEV_HUMAN, Fifth Ewing variant protein, PC12 ETS domain-containing transcription factor 1, PC12 ETS factor 1, Pet-1, Protein FEV, ENSG00000163497 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q99581 |
| Notes: | Ensembl ID: ENSG00000163497; DNA-binding domain sequence; TF family: ETS; Clone source: Gene synthesis, TF family: ETS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: ETS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 126 |
| Pfam Domains: | 23-105 Ets-domain |
| Sequence: (in bold interface residues) | 1 LFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEV 60 61 ARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAH 120 121 AAAAAA |
| Interface Residues: | 21, 76, 77, 79, 80, 81, 83, 84, 98 |
| 3D-footprint Homologues: | 3zp5_A, 1dux_F, 7jsa_J, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C |
| Binding Motifs: | FEV_DBD aCCGGAArTr FEV_2 rrCCGGAARTg FEV_methyl_1 raCMGGAARtg |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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