Transcription Factor

Accessions: T061552_1.02 (CISBP 1.02), P33749 (JASPAR 2024)
Names: MSN4, T061552_1.02;, MSN4_YEAST, Multicopy suppressor of SNF1 protein 4, Zinc finger protein MSN4
Organisms: Saccharomyces cerevisiae
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:C2H2 ZF
Length: 630
Pfam Domains: 573-596 C2H2-type zinc finger
573-596 Zinc finger, C2H2 type
587-613 Zinc-finger double domain
602-624 Zinc finger, C2H2 type
602-624 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MLVFGPNSSFVRHANKKQEDSSIMNEPNGLMDPVLSTTNVSATSSNDNSANNSISSPEYT 60
61 FGQFSMDSPHRTDATNTPILTATTNTTANNSLMNLKDTASLATNWKWKNSNNAQFVNDGE 120
121 KQSSNANGKKNGGDKIYSSVATPQALNDELKNLEQLEKVFSPMNPINDSHFNENIELSPH 180
181 QHATSPKTNLLEAEPSIYSNLFLDARLPNNANSTTGLNDNDYNLDDTNNDNTNSMQSILE 240
241 DFVSSEEALKFMPDAGRDARRYSEVVTSSFPSMTDSRNSISHSIEFWNLNHKNSSNSKPT 300
301 QQIIPEGTATTERRGSTISPTTTINNSNPNFKLLDHDVSQALSGYSMDFSKDSGITKPKS 360
361 ISSSLNRISHSSSTTRQQRASLPLIHDIESFANDSVMANPLSDSASFLSEENEDDAFGAL 420
421 NYNSLDATTMSAFDNNVDPFNILKSSPAQDQQFIKPSMMLSDNASAAAKLATSGVDNITP 480
481 TPAFQRRSYDISMNSSFKILPTSQAHHAAQHHQQQPTKQATVSPNTRRRKSSSVTLSPTI 540
541 SHNNNNGKVPVQPRKRKSITTIDPNNYDKNKPFKCKDCEKAFRRSEHLKRHIRSVHSTER 600
601 PFACMFCEKKFSRSDNLSQHLKTHKKHGDF
Interface Residues: 406, 556, 558, 573, 583, 584, 585, 586, 587, 589, 590, 591, 612, 613, 614, 615, 616, 617, 618, 619, 620, 623
3D-footprint Homologues: 8gh6_A, 2gli_A, 2kmk_A, 1g2f_F, 5v3j_F, 8cuc_F, 7y3l_A, 3uk3_C, 7n5w_A, 8ssu_A, 6u9q_A, 5und_A, 8gn3_A, 6blw_A, 5k5l_F, 2lt7_A, 7ysf_A, 6wmi_A, 4x9j_A, 2i13_A, 1llm_D, 7w1m_H, 5kkq_D, 2wbs_A, 1ubd_C, 5yel_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 6ml4_A, 5kl3_A, 2drp_D, 1f2i_J, 5k5i_A, 4m9v_C, 8h9h_G, 1tf3_A, 7y3m_I, 1tf6_A, 6e94_A, 7eyi_G, 7txc_E, 5yj3_D
Binding Motifs: M0527_1.02 yarGGGGy
MA0342.1 AGGGG
Publications: Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed]
Related annotations: PaperBLAST

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