Transcription Factor

Accessions: T099786_1.02 (CISBP 1.02), Q93899 (JASPAR 2024)
Names: T099786_1.02;, vab-7, VAB7_CAEEL
Organisms: Caenorhabditis elegans
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Homeodomain
Length: 247
Pfam Domains: 69-125 Homeobox domain
Sequence:
(in bold interface residues)
1 MQSFDIESLIGVNKVPSLVEMVAASRASSFSPPFEQQHHDPMGVVAAAAAAAAAGRHHPY 60
61 DNRDDGQMRRYRTAFSREQIGRLEREFAKENYVSRKTRGELAAELNLPEGTIKVWFQNRR 120
121 MKDKRQRVGGLAWPFPPQMAAYMLNPFAYEMWMKTAAASQFGATGPGNGAYGNNGSSTSP 180
181 SAAGSLPFLPPLGFPSFLSQNSTKSPSSPHSDDSSKSKNTSSDDDESKPVNFSNSPSSSS 240
241 PSPYSTD
Interface Residues: 58, 63, 69, 70, 71, 72, 110, 111, 113, 114, 117, 118, 121, 122, 125
3D-footprint Homologues: 3a01_E, 1puf_A, 3cmy_A, 1mnm_C, 5zfz_A, 3d1n_M, 1fjl_B, 1ig7_A, 6a8r_A, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 2ld5_A, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 1b72_A, 5hod_A, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1le8_B, 1du0_A, 1k61_B, 8g87_X, 3l1p_A, 1o4x_A, 4qtr_D
Binding Motifs: M1109_1.02 cTAATTAa
MA0927.1 cTAATTAa
Publications: Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed]
Related annotations: PaperBLAST

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