Transcription Factor
| Accessions: | P32115 (JASPAR 2024) |
| Names: | PAX4_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 349 |
| Pfam Domains: | 7-129 'Paired box' domain 172-227 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGR 60 61 YYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPS 120 121 VSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGAPRGPHPGTSHRNRTIFSPG 180 181 QAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGA 240 241 SQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSPSFCQLCCGTAPGRCSSDTSSQAYL 300 301 QPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLIGGPGQVPSTHCSNWP |
| Interface Residues: | 18, 50, 51, 53, 55, 56, 72, 75, 78, 120, 121, 122, 123, 125, 126, 129, 169, 171, 172, 173, 174, 212, 213, 215, 216, 219, 220, 223, 224, 227 |
| 3D-footprint Homologues: | 1pdn_C, 6pax_A, 1k78_A, 1mnm_C, 1puf_A, 6a8r_A, 3d1n_M, 5zfz_A, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 6es3_K, 7q3o_C, 5flv_I, 5zjt_E, 3a01_E, 2h1k_B, 5hod_A, 1au7_A, 3cmy_A, 2hdd_A, 7psx_B, 1fjl_B, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1b72_A, 4xrs_G, 2hos_A, 1ig7_A, 4cyc_A, 2xsd_C, 1le8_A, 7xrc_C, 1e3o_C, 1du0_A, 3l1p_A, 8g87_X, 1k61_B, 4qtr_D, 1o4x_A, 4j19_B |
| Binding Motifs: | MA0068.1 rAAwawwwkcmmmwacymcmcymmcmcymc PH0131.1 wsawyTAATTAryysdm |
| Publications: | Smith S. B., Ee H. C., Conners J. R., German M. S. Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19:8272-8280 (1999). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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