Transcription Factor
| Accessions: | Q66JY7 (JASPAR 2024) |
| Names: | Q66JY7_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q66JY7 |
| Length: | 628 |
| Pfam Domains: | 1-176 Hepatocyte nuclear factor 1 (HNF-1), N terminus 200-273 Homeobox domain 282-539 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus 540-627 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus |
| Sequence: (in bold interface residues) | 1 MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTEL 60 61 PNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVK 120 121 SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA 180 181 GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKSPSKEERETLVEECNRAE 240 241 CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP 300 301 AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSS 360 361 LLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPAS 420 421 LGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ 480 481 SHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQV 540 541 FTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSD 600 601 SNGHSHLLPSNHSVIETFISTQMASSSQ |
| Interface Residues: | 140, 141, 142, 143, 145, 146, 152, 153, 200, 201, 203, 263, 264, 265, 266, 269, 270, 273 |
| 3D-footprint Homologues: | 1ic8_B, 2h8r_B, 3cmy_A, 1fjl_B, 5zfz_A, 2lkx_A, 1puf_B, 4j19_B, 1le8_A |
| Binding Motifs: | PB0081.1 mctyrgTTAACyaarmr PB0185.1 tkrycygGATTAdr PH0167.1 ysktrGTTAACtaaaak |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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