Transcription Factor

						

			
Accessions: Q80W88 (JASPAR 2024)

			
Names: Homeobox and leucine zipper protein Homez, Homeodomain leucine zipper-containing factor, HOMEZ_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q80W88
Length: 542
Pfam Domains:    78-109 Homeobox KN domain
  447-501 Homeodomain leucine-zipper encoding, Homez
Sequence: 
(in bold interface residues)		   1 MLGHRLLPSLDFPAVSEGYKPEHDMSPNKDASSLNSSAAGLVCLPPVSEELQLVWTQAIQ   60
  61 TSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIE  120
 121 ETRARVVYHRDQLLFKSLLSFTQQSVRPPQERPPVLRPEQVALGLSPLAPSEQPTHMKGL  180
 181 KVEPEEPSQVSQLPLNHQNAKEPLMMGSRTFSHQSDCQDLQISGLSKEQAGRGPDQSCGK  240
 241 TASWNHFTAVHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPL  300
 301 QPLGCISQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPDMQHQRKTKRKTKE  360
 361 QLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLG  420
 421 TPSFQDPAIPTPSTRSLKEWAKTPPLPAPPPPPDIRPLEKYWAAHQQLQEADILKLSQAS  480
 481 RLSTQQVLDWFDSRLPKPAEVVVCLDEEDEEDEEDELPEDGEEEEEEEEDDDDGDDDVII  540
 541 WD
Interface Residues: 52, 101, 104, 105, 108, 109, 396, 399, 400, 404, 485, 486, 489, 492, 493, 496, 497, 500
3D-footprint Homologues: 5zfz_A, 1puf_B, 6a8r_A, 3lnq_A, 1du0_A, 2ld5_A, 7psx_B
Binding Motifs: PH0044.1 awwwmATCGTTTttadd
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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