Transcription Factor
| Accessions: | EcR/usp (DrosophilaTF 1.1), T134206_1.02 (CISBP 1.02), P34021 (JASPAR 2024) |
| Names: | 20-hydroxy-ecdysone receptor, 20E receptor, Ecdysone receptor, Ecdysteroid receptor, ECR_DROME, EcRH, Nuclear receptor subfamily 1 group H member 1, EcR, T134206_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P34021 |
| Notes: | experiment type:B1H, family:Nuclear receptor |
| Length: | 878 |
| Pfam Domains: | 263-330 Zinc finger, C4 type (two domains) 453-626 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MKRRWSNNGGFMRLPEESSSEVTSSSNGLVLPSGVNMSPSSLDSHDYCDQDLWLCGNESG 60 61 SFGGSNGHGLSQQQQSVITLAMHGCSSTLPAQTTIIPINGNANGNGGSTNGQYVPGATNL 120 121 GALANGMLNGGFNGMQQQIQNGHGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHH 180 181 ANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGY 240 241 SANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCC 300 301 KFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSP 360 361 SSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQ 420 421 LAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKG 480 481 LPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADN 540 541 IEDLLHFCRQMFSMKVDNVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNR 600 601 HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQ 660 661 SHLQITQEENERLERAERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQPQPSSL 720 721 TQNDSQHQTQPQLQPQLPPQLQGQLQPQLQPQLQTQLQPQIQPQPQLLPVSAPVPASVTA 780 781 PGSLSAVSTSSEYMGGSAAIGPITPATTSSITAAVTASSTTSAVPMGNGVGVGVGVGGNV 840 841 SMYANAQTAMALMGVALHSHQEQLIGGVAVKSEHSTTA |
| Interface Residues: | 272, 273, 275, 276, 282, 283, 285, 286, 289, 290, 314, 343, 353 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A |
| Binding Motifs: | EcR/usp rrGGTCAaTGACCyC MA0534.1 vrGkTyRwTGmmyyy M4933_1.02 wTGACCTy MA2223.1 rAGGTCAw |
| Binding Sites: | MA0534.1.1 MA0534.1.10 MA0534.1.11 MA0534.1.12 MA0534.1.13 MA0534.1.14 MA0534.1.15 MA0534.1.16 MA0534.1.17 MA0534.1.18 MA0534.1.19 MA0534.1.2 MA0534.1.20 MA0534.1.3 MA0534.1.4 MA0534.1.5 MA0534.1.6 MA0534.1.7 MA0534.1.8 MA0534.1.9 |
| Publications: | Vögtli M, Elke C, Imhof M.O, Lezzi M. High level transactivation by the ecdysone receptor complex at the core recognition motif. Nucleic acids research 26:2407-14 (1998). [Pubmed] Antoniewski C, Mugat B, Delbac F, Lepesant J.A. Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster. Molecular and cellular biology 16:2977-86 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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