Transcription Factor
| Accessions: | SMAD4_MOUSE (HOCOMOCO 10), P97471 (JASPAR 2024) |
| Names: | Deletion target in pancreatic carcinoma 4 homolog, MAD homolog 4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4, SMAD4_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P97471 |
| Length: | 551 |
| Pfam Domains: | 37-137 MH1 domain 318-530 MH2 domain |
| Sequence: (in bold interface residues) | 1 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA 60 61 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD 120 121 LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQT 180 181 IQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIA 240 241 SGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHY 300 301 WPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDR 360 361 FCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRA 420 421 PGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPA 480 481 ISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLH 540 541 TMPIADPQPLD |
| Interface Residues: | 79, 81, 83, 88, 353, 360 |
| 3D-footprint Homologues: | 6fzs_A, 5od6_A, 6h3r_A, 5nm9_A, 5mey_A, 5j0n_F |
| Binding Motifs: | SMAD4_MOUSE.H10MO.C|M01337 tGTCTGkmy MA1153.1 tGTCTrGm MA1153.2 yGTCTrG |
| Publications: | Lee KH, Evans S, Ruan TY, Lassar AB. SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2. 5 enhancer 131:4709-23 (Development.). [Pubmed] |
| Related annotations: | PaperBLAST |
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