Transcription Factor

Accessions: Q9ER75 (JASPAR 2024)
Names: Homeodomain protein IRXB3, Iroquois homeobox protein 6, Iroquois-class homeodomain protein IRX-6, IRX6_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9ER75
Length: 438
Pfam Domains: 146-203 Homeobox domain
161-200 Homeobox KN domain
Sequence:
(in bold interface residues)
1 MAFSPFGHPYGSTSQFLVSASSSATCCETAPRPVSDVASASTSASTLCCTPYDSRLLGSA 60
61 RPELGAALGIYGAPYAAAQSYPGYLTYGPEPPTLCGALNPQYEFKDAAGSFAPSLTQPGA 120
121 YYPYETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLA 180
181 IITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKDATA 240
241 SQEARGLRLSDLEDLEEEEEEEEAEEEAAVSAARRLADFQKSTQPLPAPCAAAQERCLES 300
301 RECGLGLPRFSFTEAPQSGEADFITAEPGGPTMILHYPSGHKPRIWSLAHTAAASAVESA 360
361 PSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEGEEDSPAAKAFGNSTFTLQGLPLNCAPY 420
421 PRRREPEVRFQYPSGAEG
Interface Residues: 144, 145, 146, 147, 148, 149, 150, 154, 188, 189, 191, 192, 195, 196, 197, 199, 200, 202, 203, 216, 219
3D-footprint Homologues: 1puf_A, 3d1n_M, 6fqp_B, 5jlw_D, 1au7_A, 2r5y_A, 1puf_B, 1b72_A, 3a01_E, 4cyc_A, 2lkx_A, 2ld5_A, 3rkq_B, 2h1k_B, 1ig7_A, 3cmy_A, 1le8_B, 6fqq_E, 4xrm_B, 1fjl_B, 5zfz_A, 2hdd_A, 1mnm_C, 7psx_B, 4xrs_G, 5zjt_E, 1nk2_P, 5flv_I, 2d5v_B, 1k61_B, 1o4x_A, 1du0_A, 2hos_A
Binding Motifs: PH0087.1 wawrTACATGTAmwwwT
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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