Transcription Factor
| Accessions: | tll (DrosophilaTF 1.1), T134213_1.02 (CISBP 1.02), P18102 (JASPAR 2024) |
| Names: | Nuclear receptor subfamily 2 group E member 2, Protein tailless, TLL_DROME, T134213_1.02;, tll |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Nuclear receptor |
| Length: | 452 |
| Pfam Domains: | 33-103 Zinc finger, C4 type (two domains) 230-433 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKR 60 61 SIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRH 120 121 MAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPS 180 181 AAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHL 240 241 FKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANR 300 301 EIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTG 360 361 SGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKV 420 421 SSFTIEELFFRKTIGDITIVRLISDMYSQRKI |
| Interface Residues: | 42, 43, 45, 46, 52, 53, 55, 56, 59, 60, 64, 66, 70, 86, 108, 110, 112, 113 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_A, 1hcq_E, 8cef_H, 2han_B, 1kb2_B, 2a66_A, 8hbm_B, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 7xv6_B, 4iqr_B, 5cbx_B, 3g6t_A, 1r4i_A, 7prw_B, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 5f0q_A |
| Binding Motifs: | MA0459.1 aAAAGTCAAm tll AAATTAA M1471_1.02 aaaTTGACsTca |
| Binding Sites: | MA0459.1.1 MA0459.1.10 MA0459.1.11 MA0459.1.12 MA0459.1.13 MA0459.1.14 MA0459.1.15 MA0459.1.16 MA0459.1.17 MA0459.1.18 MA0459.1.19 MA0459.1.2 MA0459.1.20 MA0459.1.3 MA0459.1.4 MA0459.1.5 MA0459.1.6 MA0459.1.7 MA0459.1.8 MA0459.1.9 |
| Publications: | Hoch M., Gerwin N., Taubert H., Jaeckle H. Competition for overlapping sites in the regulatory region of the Drosophila gene Krueppel. Science 256:94-97 (1992). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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