Transcription Factor
| Accessions: | P11474 (JASPAR 2024) |
| Names: | ERR-alpha, ERR1_HUMAN, Estrogen receptor-like 1, Estrogen-related receptor alpha, Nuclear receptor subfamily 3 group B member 1, Steroid hormone receptor ERR1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P11474 |
| Length: | 423 |
| Pfam Domains: | 78-145 Zinc finger, C4 type (two domains) 226-398 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAG 60 61 PGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE 120 121 CEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGP 180 181 LAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTI 240 241 SWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAA 300 301 GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALL 360 361 EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA 420 421 MMD |
| Interface Residues: | 87, 88, 90, 91, 97, 98, 100, 101, 104, 105, 129, 151, 153, 155, 158, 160, 175 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1a6y_A, 1lo1_A, 3g9m_B, 4oln_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E |
| Binding Motifs: | MA0592.1 yCAAGGTCAcm MA0592.3 kytCAAGGTCAya MA0592.4 tCAAGGTCA |
| Binding Sites: | MA0592.1.1 MA0592.1.10 MA0592.1.11 MA0592.1.12 MA0592.1.13 MA0592.1.14 MA0592.1.15 MA0592.1.16 MA0592.1.17 MA0592.1.18 MA0592.1.19 MA0592.1.2 MA0592.1.20 MA0592.1.3 MA0592.1.4 MA0592.1.5 / MA0592.1.8 MA0592.1.6 MA0592.1.7 MA0592.1.9 MA0592.3.1 MA0592.3.10 / MA0592.3.6 MA0592.3.11 / MA0592.3.7 MA0592.3.12 MA0592.3.13 / MA0592.3.8 MA0592.3.14 / MA0592.3.9 MA0592.3.10 / MA0592.3.15 MA0592.3.11 / MA0592.3.16 MA0592.3.12 / MA0592.3.17 MA0592.3.13 / MA0592.3.18 MA0592.3.14 / MA0592.3.19 MA0592.3.2 MA0592.3.20 MA0592.3.3 MA0592.3.4 MA0592.3.5 MA0592.3.6 MA0592.3.4 / MA0592.3.7 MA0592.3.5 / MA0592.3.8 MA0592.3.9 MA0592.3.15 MA0592.3.16 MA0592.3.17 MA0592.3.18 MA0592.3.19 MA0592.3.20 MA0592.4.1 / MA0592.4.10 / MA0592.4.19 / MA0592.4.5 / MA0592.4.8 MA0592.4.11 / MA0592.4.15 MA0592.4.12 MA0592.4.13 MA0592.4.14 MA0592.4.16 / MA0592.4.17 / MA0592.4.9 MA0592.4.18 MA0592.4.2 MA0592.4.20 MA0592.4.3 MA0592.4.4 MA0592.4.6 MA0592.4.7 |
| Publications: | Dufour C. R., Wilson B. J., Huss J. M., Kelly D. P., Alaynick W. A., Downes M., Evans R. M., Blanchette M., Giguere V. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.. Cell Metab. 5:345-356 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.