Transcription Factor
| Accessions: | ERR2_MOUSE (HOCOMOCO 10), Q61539 (JASPAR 2024) |
| Names: | ERR-beta, ERR2_MOUSE, Estrogen receptor-like 2, Estrogen-related receptor beta, Nuclear receptor subfamily 3 group B member 2, Steroid hormone receptor ERR2 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q61539 |
| Length: | 433 |
| Pfam Domains: | 102-169 Zinc finger, C4 type (two domains) 239-423 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MSSEDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGIALSTHANGLDSPP 60 61 MFAGAGLGGNPCRKSYEDCTSGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASC 120 121 EACKAFFKRTIQGNIEYNCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRG 180 181 GRQKYKRRLDSENSPYLNLPISPPAKKPLTKIVSNLLGVEQDKLYAMPPNDIPEGDIKAL 240 241 TTLCELADRELVFLINWAKHIPGFPSLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLA 300 301 YAEDYIMDEEHSRLVGLLDLYRAILQLVRRYKKLKVEKEEFMILKALALANSDSMYIENL 360 361 EAVQKLQDLLHEALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 420 421 MHKLFLEMLEAKV |
| Interface Residues: | 111, 112, 114, 115, 121, 122, 124, 125, 128, 129, 153, 175, 177, 179, 182, 184 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B |
| Binding Motifs: | ERR2_MOUSE.H10MO.B|M01076 yCAAGGTCA MA0141.1 rgsyCAAGGTCA MA0141.2 rgsyCAAGGTCA |
| Binding Sites: | MA0141.1.1 MA0141.1.10 MA0141.1.11 MA0141.1.12 MA0141.1.13 MA0141.1.14 MA0141.1.15 MA0141.1.16 MA0141.1.17 MA0141.1.18 MA0141.1.19 MA0141.1.2 MA0141.1.20 MA0141.1.3 MA0141.1.4 MA0141.1.5 MA0141.1.6 MA0141.1.7 MA0141.1.8 MA0141.1.9 |
| Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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