Transcription Factor
| Accessions: | T093335_1.02 (CISBP 1.02), Q92826 (JASPAR 2024) |
| Names: | HOXB13, T093335_1.02;, HXB13_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 284 |
| Pfam Domains: | 21-123 Hox protein A13 N terminal 217-273 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPP 60 61 KQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEY 120 121 PSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNS 180 181 QMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKF 240 241 ITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP |
| Interface Residues: | 215, 217, 218, 219, 220, 258, 259, 261, 262, 265, 266, 269, 270, 273 |
| 3D-footprint Homologues: | 6fqp_B, 1ig7_A, 2h1k_B, 1puf_A, 3cmy_A, 6a8r_A, 1fjl_B, 5zfz_A, 2lkx_A, 1jgg_B, 3lnq_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 5flv_I, 3a01_E, 5zjt_E, 4cyc_A, 2hdd_A, 2r5y_A, 1puf_B, 6m3d_C, 5jlw_D, 2hos_A, 4xrs_G, 7psx_B, 1b72_A, 3rkq_B, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 6fqq_E, 5hod_A, 1mnm_C, 4qtr_D, 1k61_B |
| Binding Motifs: | MA0901.1 CCaATAAAAm M0897_1.02 tTTwAydrgs UN0487.1 symrTAAAhATyGATy MA1932.1 rCCGGAAGThrTAAAa MA1937.1 rccGGAaryhrTwAaa MA1943.1 aCCGGAwmyATwAAm UN0531.1 ACCGGAAGTCRTAAAa UN0559.1 rcmGGAAGycrTAAAm MA0901.2 wwcCAATAAAAwww MA0901.3 cCAATAAAA MA1932.2 rCCGGAAGThrTAAA MA1937.2 cGGAaryhrTwAa MA1943.2 CCGGAwmyATwAA UN0559.2 rcmGGAAGycrTAAA |
| Binding Sites: | MA0901.2.1 MA0901.2.10 MA0901.2.11 / MA0901.2.7 MA0901.2.12 / MA0901.2.8 MA0901.2.13 / MA0901.2.9 MA0901.2.10 / MA0901.2.14 MA0901.2.15 MA0901.2.11 / MA0901.2.16 MA0901.2.12 / MA0901.2.17 MA0901.2.13 / MA0901.2.18 MA0901.2.19 MA0901.2.2 MA0901.2.20 MA0901.2.3 MA0901.2.3 / MA0901.2.4 MA0901.2.5 MA0901.2.4 / MA0901.2.6 MA0901.2.7 MA0901.2.5 / MA0901.2.8 MA0901.2.6 / MA0901.2.9 MA0901.2.14 MA0901.2.15 MA0901.2.16 MA0901.2.17 MA0901.2.18 MA0901.2.19 MA0901.2.2 MA0901.2.20 MA0901.3.1 / MA0901.3.15 / MA0901.3.17 / MA0901.3.9 MA0901.3.10 / MA0901.3.19 MA0901.3.11 / MA0901.3.12 / MA0901.3.5 MA0901.3.13 / MA0901.3.14 / MA0901.3.20 / MA0901.3.7 MA0901.3.16 MA0901.3.18 MA0901.3.2 MA0901.3.3 / MA0901.3.4 MA0901.3.6 MA0901.3.8 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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