Transcription Factor

Accessions: Q01822 (JASPAR 2024)
Names: Homeobox protein Hox-4.9, Homeobox protein Hox-D1, HXD1_MOUSE
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q01822
Length: 328
Pfam Domains: 233-286 Homeobox domain
Sequence:
(in bold interface residues)
1 MSSYLEYVSCAAGGGSGGVGGDVLGFAPKFCRADARPVALQPAFPLGSGDGAFVSCLPLA 60
61 TARPTPSPPAGPAQSPVPQPAAPRYAPCTLEGAYERGAAPASAAEYGFLGSGPAFDFPGA 120
121 LGRAADEGGAHVHYATSAVFSGGGSFLLSGQVDFAAFGEPGPFPACLKEPADGHPGPFQT 180
181 VSPAPGACPKPASPTSSLPAAHSTFEWMKVKRNAPKKSKLSEYGATSPPSAIRTNFSTKQ 240
241 LTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVA 300
301 SIKLPRSETSPIKSGRNLGSPSQAQEPS
Interface Residues: 217, 226, 230, 231, 233, 271, 272, 274, 275, 278, 279, 282, 283, 286
3D-footprint Homologues: 5zfz_A, 3a01_E, 3d1n_M, 1zq3_P, 1puf_B, 1fjl_B, 6es3_K, 4xrs_G, 2hos_A, 1nk2_P, 1b72_A, 4cyc_A, 1ig7_A, 6m3d_C, 5flv_I, 2ld5_A, 5zjt_E, 4j19_B, 2h1k_B, 1jgg_B, 7psx_B, 5hod_A, 3lnq_A, 2lkx_A, 1puf_A, 6a8r_A, 3cmy_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 1au7_A, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: PH0074.1 wraryTAATTArytgkw
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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