Transcription Factor

Accessions: Q21446 (JASPAR 2024)
Names: Abnormal cell lineage protein 14, LIN14_CAEEL, Protein lin-14
Organisms: Caenorhabditis elegans
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 539
Sequence:
(in bold interface residues)
1 MGKGQPKEPKIEQSVVDLCKRTVAMNLLQCYPTTTVDEMNCEEWGNGTESTQSVAACQGC 60
61 IELRKEVTDLRQAVNLILPMLPLYPTIGNGFNATGLAAQPTLQHVIQQSLLRKRPVAQTP 120
121 TVPQPECPGQIRPVLSSPAAALQNVIMLNPWIMGSSLKPASPTLPNGQIPTTIGETSLQG 180
181 TDDQTVKWIGPSSVDSNGQKTDSSAASAGDNQNIDVIGDGSESPTSSNHSAQEIALMTSQ 240
241 QTFLNALKDSSFLFTNPVPTVETAPPLRVAPPINGTTNGTAKAGGPERKPRKPVNDDIVK 300
301 IVRNQDLSEENISMFEIPVPKAIASDPTFRPVSEQQIIQQIIQGKKYEEMEVGECMIQLC 360
361 KKLAEKRVFGPRLMSQTTVAGLNHSNYANLPIKGICYIQHVCRKVLYDKFENEEDFWDKF 420
421 REAMRKLAARCRRVRHAKKTKHNREEAQAEMLSKRYGEDMPFNLNGAGLIRPKVETVSPE 480
481 ANILNSDQIKSQLESLFAHIPKTESETPLIEIIQQNISLFTHLIRTKVESQSPPLQGPQ
Interface Residues: 60, 62, 64, 68, 81, 96, 99, 100, 103, 104, 171, 172, 179, 181, 184, 186, 188, 320, 324, 325, 326, 327, 339, 343
3D-footprint Homologues: 4lq0_A, 1lq1_D, 7et4_D, 6obj_A, 4xvk_A
Binding Motifs: MA0261.1 GAACrc
Binding Sites: MA0261.1.1
MA0261.1.10
MA0261.1.11
MA0261.1.12
MA0261.1.13
MA0261.1.14
MA0261.1.15
MA0261.1.16
MA0261.1.17
MA0261.1.18
MA0261.1.19
MA0261.1.2
MA0261.1.20
MA0261.1.3
MA0261.1.4
MA0261.1.5
MA0261.1.6
MA0261.1.7
MA0261.1.8
MA0261.1.9
Publications: Hristova M, Birse D, Hong Y, Ambros V. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Molecular and cellular biology 25:11059-72 (2005). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.