Transcription Factor
| Accessions: | ZNF574 (humanC2H2ZF-ChIP Feb2015), Q6ZN55 (JASPAR 2024) |
| Names: | ENSG00000105732, Q6ZN55, ZNF574, ZN574_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2 experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 896 |
| Pfam Domains: | 16-38 C2H2-type zinc finger 126-149 C2H2-type zinc finger 213-235 C2H2-type zinc finger 309-332 Zinc-finger of C2H2 type 310-333 C2H2-type zinc finger 311-331 C2H2-type zinc finger 324-345 Zinc-finger double domain 335-347 C2H2-type zinc finger 336-358 C2H2-type zinc finger 336-355 Zinc finger, C2H2 type 336-355 Zinc-finger of C2H2 type 364-386 C2H2-type zinc finger 396-413 C2H2-type zinc finger 465-487 C2H2-type zinc finger 481-505 Zinc-finger double domain 495-504 C2H2-type zinc finger 495-517 C2H2-type zinc finger 495-517 Zinc finger, C2H2 type 496-516 Zinc-finger of C2H2 type 510-533 Zinc-finger double domain 523-545 Zinc finger, C2H2 type 523-545 C2H2-type zinc finger 537-562 Zinc-finger double domain 551-573 Zinc finger, C2H2 type 551-573 C2H2-type zinc finger 551-573 C2H2-type zinc finger 579-599 C2H2-type zinc finger 594-616 Zinc-finger double domain 607-630 C2H2-type zinc finger 635-655 C2H2-type zinc finger 738-758 C2H2-type zinc finger 739-760 Zinc finger, C2H2 type 739-760 C2H2-type zinc finger 752-776 Zinc-finger double domain 766-788 Zinc finger, C2H2 type 766-788 C2H2-type zinc finger 766-788 C2H2-type zinc finger 780-804 Zinc-finger double domain 809-832 Zinc-finger double domain 822-844 C2H2-type zinc finger 822-844 Zinc finger, C2H2 type 822-844 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MTEESEETVLYIEHRYVCSECNQLYGSLEEVLMHQNSHVPQQHFELVGVADPGVTVATDT 60 61 ASGTGLYQTLVQESQYQCLECGQLLMSPSQLLEHQELHLKMMAPQEAVPAEPSPKAPPLS 120 121 SSTIHYECVDCKALFASQELWLNHRQTHLRATPTKAPAPVVLGSPVVLGPPVGQARVAVE 180 181 HSYRKAEEGGEGATVPSAAATTTEVVTEVELLLYKCSECSQLFQLPADFLEHQATHFPAP 240 241 VPESQEPALQQEVQASSPAEVPVSQPDPLPASDHSYELRNGEAIGRDRRGRRARRNNSGE 300 301 AGGAATQELFCSACDQLFLSPHQLQQHLRSHREGVFKCPLCSRVFPSPSSLDQHLGDHSS 360 361 ESHFLCVDCGLAFGTEALLLAHRRAHTPNPLHSCPCGKTFVNLTKFLYHRRTHGVGGVPL 420 421 PTTPVPPEEPVIGFPEPAPAETGEPEAPEPPVSEETSAGPAAPGTYRCLLCSREFGKALQ 480 481 LTRHQRFVHRLERRHKCSICGKMFKKKSHVRNHLRTHTGERPFPCPDCSKPFNSPANLAR 540 541 HRLTHTGERPYRCGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLMHRYH 600 601 HTGEYPYKCRECPRSFLLRRLLEVHQLVVHAGRQPHRCPSCGAAFPSSLRLREHRCAAAA 660 661 AQAPRRFECGTCGKKVGSAARLQAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAA 720 721 LGSTATASPAAPARRRGLECSECKKLFSTETSLQVHRRIHTGERPYPCPDCGKAFRQSTH 780 781 LKDHRRLHTGERPFACEVCGKAFAISMRLAEHRRIHTGERPYSCPDCGKSYRSFSNLWKH 840 841 RKTHQQQHQAAVRQQLAEAEAAVGLAVMETAVEALPLVEAIEIYPLAEAEGVQISG |
| Interface Residues: | 320, 322, 323, 477, 478, 479, 480, 482, 483, 487, 505, 506, 507, 508, 509, 511, 512, 533, 534, 535, 536, 537, 540, 543, 561, 562, 563, 564, 565, 568, 570, 590, 591, 592, 593, 596, 618, 619, 620, 621, 624, 646, 647, 649, 650, 653, 678, 679, 680, 681, 684, 686, 717, 719, 720, 733, 738, 747, 748, 749, 750, 751, 752, 754, 755, 757, 758, 759, 761, 776, 777, 778, 779, 780, 782, 783, 787, 804, 805, 806, 807, 808, 809, 810, 811, 812, 832, 833, 834, 835, 836, 837, 838, 839, 840 |
| 3D-footprint Homologues: | 5k5l_F, 8ssu_A, 2i13_A, 5kkq_D, 2drp_D, 8ssq_A, 7w1m_H, 7ysf_A, 8cuc_F, 7y3l_A, 1tf3_A, 1tf6_A, 5und_A, 8h9h_G, 2lt7_A, 8gn3_A, 2wbs_A, 5yj3_D, 5k5i_A, 5v3j_F, 7txc_E, 5yel_A, 2kmk_A, 7n5w_A, 3uk3_C, 2gli_A, 6ml4_A, 4x9j_A, 6blw_A, 5ei9_F, 7eyi_G, 7y3m_I, 6e94_A, 6wmi_A, 2jpa_A, 1ubd_C, 6jnm_A, 1g2f_F, 1llm_D, 6u9q_A, 1mey_C, 5kl3_A, 1f2i_J, 6a57_A, 4m9v_C |
| Binding Motifs: | ZNF574_ChIP cCkCTCTAG MA1982.1 sksCTAGAGmGGCcs MA1982.2 ksCTAGAGmGGCcs |
| Publications: | ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489:57-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.