Transcription Factor

						

			
Accessions: Q12837 (JASPAR 2024)

			
Names: Brain-3B, Brain-specific homeobox/POU domain protein 3B, Brn-3B, PO4F2_HUMAN, POU domain, class 4, transcription factor 2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q12837
Length: 409
Pfam Domains:   253-327 Pou domain - N-terminal to homeobox domain
  346-402 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG   60
  61 GGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIV  120
 121 SQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHH  180
 181 HHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHG  240
 241 LPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC  300
 301 RFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSL  360
 361 EAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
Interface Residues: 276, 277, 295, 296, 297, 298, 300, 301, 302, 303, 306, 307, 308, 309, 311, 346, 347, 348, 349, 350, 387, 388, 390, 391, 394, 395, 398, 399, 402
3D-footprint Homologues: 7u0g_M, 3l1p_A, 3cro_R, 3d1n_M, 1o4x_A, 1e3o_C, 7xrc_C, 1au7_A, 8g87_X, 2xsd_C, 2d5v_B, 6a8r_A, 1puf_A, 3cmy_A, 2h1k_B, 5zfz_A, 1fjl_B, 1ig7_A, 1jgg_B, 2lkx_A, 3lnq_A, 1nk2_P, 1zq3_P, 6es3_K, 7q3o_C, 2ld5_A, 3a01_E, 2r5y_A, 1puf_B, 7psx_B, 5flv_I, 2hdd_A, 1b72_A, 5zjt_E, 3rkq_B, 5hod_A, 5jlw_D, 1le8_A, 1du0_A, 4qtr_D, 4xrs_G
Binding Motifs: MA0683.1 aTGmATAATTAATkAg
MA0683.2 TGmATAATTAATkAg
			
Publications: Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135:271-80 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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