Transcription Factor

						

			
Accessions: P23760 (JASPAR 2024)

			
Names: HuP2, Paired box protein Pax-3, PAX3_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 479
Pfam Domains:    34-159 'Paired box' domain
  220-276 Homeobox domain
  346-391 Paired box protein 7 
Sequence: 
(in bold interface residues)		   1 MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV   60
  61 EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEE  120
 121 YKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEES  180
 181 EKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER  240
 241 THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMP  300
 301 TLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTR  360
 361 HGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLE  420
 421 PTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF
Interface Residues: 47, 79, 80, 82, 84, 85, 101, 104, 107, 150, 151, 152, 153, 155, 156, 159, 219, 220, 221, 222, 223, 261, 262, 264, 265, 268, 269, 272, 273, 276
3D-footprint Homologues: 1k78_A, 6pax_A, 1pdn_C, 4j19_B, 5zfz_A, 2h1k_B, 1fjl_B, 1puf_A, 3cmy_A, 1ig7_A, 1puf_B, 6a8r_A, 3d1n_M, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 1jgg_B, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 1au7_A, 3a01_E, 5flv_I, 5zjt_E, 1b72_A, 2hdd_A, 5hod_A, 3rkq_B, 2r5y_A, 2hos_A, 7psx_B, 5jlw_D, 4cyc_A, 4xrs_G, 3l1p_A, 7xrc_C, 1le8_A, 2xsd_C, 1e3o_C, 1k61_B, 1mnm_C, 4qtr_D, 8g87_X, 1du0_A, 4xrm_B, 1o4x_A, 1le8_B
Binding Motifs: MA0780.1 TAATyrATTA
MA1546.1 ysGTCACGsywATTAr
MA1546.2 sGTCACGsywATTA
			
Publications: Kumar D., Shadrach J. L., Wagers A. J., Lassar A. B. Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells.. Mol. Biol. Cell 20:3170-3177 (2009). [Pubmed]


Epstein JA, Song B, Lakkis M, Wang C. Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol Cell Biol 18:4118-30 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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