Transcription Factor
| Accessions: | O60548 (JASPAR 2024) |
| Names: | Forkhead box protein D2, Forkhead-related protein FKHL17, Forkhead-related transcription factor 9, FOXD2_HUMAN, FREAC-9 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O60548 |
| Length: | 495 |
| Pfam Domains: | 127-222 Fork head domain |
| Sequence: (in bold interface residues) | 1 MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGELPARSGPRAPRDVLPHGHEPPA 60 61 EEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGAA 120 121 TRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLS 180 181 LNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPE 240 241 LLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAAA 300 301 AAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGLPAFLGAEL 360 361 GCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGGAGGGGAGAGQRPSFSIDHIMGH 420 421 GGGGAAPPGAGEGSPGPPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLSHPGDALLSSG 480 481 SRFASKVAGLSGCHF |
| Interface Residues: | 170, 172, 173, 174, 176, 177, 178, 180, 181, 190, 197, 219, 222 |
| 3D-footprint Homologues: | 7vox_H, 2hdc_A, 7yz7_A, 6el8_A, 7tdx_A, 3l2c_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 3qrf_G |
| Binding Motifs: | MA0847.1 rTAAAYA MA0847.2 sywAwRTAAAYAw MA0847.3 syTAAryAAACA MA0847.4 yTAAryAAACA |
| Publications: | Kaufmann E., Mueller D., Knoechel W. DNA recognition site analysis of Xenopus winged helix proteins. J. Mol. Biol. 248:239-254 (1995). [Pubmed] Tokuhiro SI, Tokuoka M, Kobayashi K, Kubo A, Oda-Ishii I, Satou Y. Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd. PLoS Genet : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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