Transcription Factor
| Accessions: | BARX2 (HT-SELEX2 May2017), Q9UMQ3 (JASPAR 2024) |
| Names: | BARX2, ENSG00000043039, BARX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UMQ3 |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 279 |
| Pfam Domains: | 134-190 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHS 60 61 CTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQVTEAVSAEAPGGEALASSE 120 121 SETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTW 180 181 YQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQEQLEPSQGQ 240 241 EELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS |
| Interface Residues: | 91, 115, 118, 119, 122, 125, 134, 135, 136, 137, 138, 175, 176, 178, 179, 182, 183, 186, 187, 190 |
| 3D-footprint Homologues: | 1zgw_A, 5zfz_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 1puf_A, 1ig7_A, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 1mnm_C, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 5hod_A, 1puf_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3a01_E, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 1le8_A, 1le8_B, 7psx_B, 1du0_A, 4xrm_B, 1k61_B, 3l1p_A, 8g87_X, 5zjt_E, 4qtr_D |
| Binding Motifs: | BARX2_2 / MA1471.1 awwAAymRTTAs BARX2_methyl_1 awwAAymrTTAm MA1471.2 wAAymRTTA |
| Publications: | Meech R, Kallunki P, Edelman GM, Jones FS. A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins. Proc Natl Acad Sci U S A 96:2420-5 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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