Transcription Factor
| Accessions: | Q99MA9 (JASPAR 2024) |
| Names: | Homeobox protein NK-6 homolog A, Homeobox protein Nkx-6.1, NKX61_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q99MA9 |
| Length: | 365 |
| Pfam Domains: | 238-294 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSP 60 61 SPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASP 120 121 SGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSP 180 181 SAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHT 240 241 RPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEM 300 301 ATAKKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASE 360 361 AEGSS |
| Interface Residues: | 236, 237, 238, 239, 241, 243, 279, 280, 282, 283, 286, 287, 290, 291, 293, 294 |
| 3D-footprint Homologues: | 5zfz_A, 3cmy_A, 3a01_E, 1puf_A, 1fjl_B, 3d1n_M, 2ld5_A, 6a8r_A, 2h1k_B, 2lkx_A, 1nk2_P, 1zq3_P, 3lnq_A, 6es3_K, 4xrs_G, 2hdd_A, 7q3o_C, 1b72_A, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 1jgg_B, 5hod_A, 3l1p_A, 7psx_B, 5jlw_D, 1mnm_C, 1ig7_A, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 1au7_A, 1du0_A, 1o4x_A, 8g87_X, 4qtr_D, 6wig_A, 6m3d_C |
| Binding Motifs: | PH0118.1 gmwwATTAATTAmyybg PH0119.1 rrtwATTAATKAykyc UN0257.1 wwTAATGAgww |
| Binding Sites: | UN0257.1.1 UN0257.1.10 UN0257.1.11 UN0257.1.12 UN0257.1.13 UN0257.1.14 UN0257.1.15 UN0257.1.16 UN0257.1.17 UN0257.1.18 UN0257.1.19 UN0257.1.2 UN0257.1.20 UN0257.1.3 UN0257.1.4 UN0257.1.5 UN0257.1.6 UN0257.1.7 UN0257.1.8 UN0257.1.9 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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