Transcription Factor
| Accessions: | PIT1_HUMAN (HOCOMOCO 10), P28069 (JASPAR 2024) |
| Names: | GHF-1, Growth hormone factor 1, PIT-1, PIT1_HUMAN, Pituitary-specific positive transcription factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 291 |
| Pfam Domains: | 125-198 Pou domain - N-terminal to homeobox domain 215-271 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHY 60 61 GNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEE 120 121 PIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSF 180 181 KNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPS 240 241 SQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR |
| Interface Residues: | 150, 166, 167, 168, 169, 171, 172, 174, 175, 178, 182, 215, 216, 217, 218, 256, 257, 259, 260, 263, 264, 267, 268, 271 |
| 3D-footprint Homologues: | 3d1n_M, 7u0g_M, 3l1p_A, 7xrc_C, 1e3o_C, 8g87_X, 1au7_A, 2xsd_C, 1o4x_A, 2d5v_B, 5zfz_A, 3cmy_A, 1fjl_B, 6a8r_A, 1ig7_A, 2lkx_A, 1zq3_P, 1nk2_P, 7q3o_C, 2ld5_A, 6es3_K, 2h1k_B, 1jgg_B, 3lnq_A, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 2hos_A, 1b72_A, 5hod_A, 3a01_E, 1le8_A, 1puf_A, 7psx_B, 5zjt_E, 4cyc_A, 1du0_A, 4qtr_D |
| Binding Motifs: | MA0784.1 awTATGCwAATkAg PIT1_HUMAN.H10MO.C|M01434 ytmaTGaAWAWwy MA0784.2 avCTmATTwGCATAwt MA0784.3 CTmATTwGCATAwt |
| Publications: | Ingraham H. A., Flynn S. E., Voss J. W., Albert V. R., Kapiloff M. S., Wilson L., Rosenfeld M. G. The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell 61:1021-1033 (1990). [Pubmed] |
| Related annotations: | PaperBLAST |
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