Transcription Factor
| Accessions: | ARNT_MOUSE (HOCOMOCO 10), P53762 (JASPAR 2024) |
| Names: | ARNT protein, ARNT_MOUSE, Aryl hydrocarbon receptor nuclear translocator, Dioxin receptor, nuclear translocator, HIF-1-beta, HIF1-beta, Hypoxia-inducible factor 1-beta |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P53762 |
| Length: | 791 |
| Pfam Domains: | 91-142 Helix-loop-helix DNA-binding domain 166-269 PAS fold 369-439 PAS fold 370-464 PAS domain 374-460 PAS fold |
| Sequence: (in bold interface residues) | 1 MAATTANPEMTSDVPSLGPTIASGNPGPGIQGGGAVVQRAIKRRSGLDFDDEVEVNTKFL 60 61 RCDDDQMCNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS 120 121 ALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS 180 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLK 240 241 TGTVKKEGQQSSMRMCMGSRRSFICRMRCGTSSVDPVSMNRLSFLRNRCRNGLGSVKEGE 300 301 PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQP 360 361 TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG 420 421 QVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIP 480 481 RSQLGPTANLSLEMGTGQLPSRQQQQQHTELDMVPGRDGLASYNHSQVSVQPVASAGSEH 540 541 SKPLEKSEGLFAQDRDPRFPEIYPSITADQSKGISSSTVPATQQLFSQGSSFPPNPRPAE 600 601 NFRNSGLTPPVTIVQPSSSAGQILAQISRHSNPAQGSAPTWTSSSRPGFAAQQVPTQATA 660 661 KTRSSQFGVNNFQTSSSFSAMSLPGAPTASSGTAAYPALPNRGSNFPPETGQTTGQFQAR 720 721 TAEGVGVWPQWQGQQPHHRSSSSEQHVQQTQAQAPSQPEVFQEMLSMLGDQSNTYNNEEF 780 781 PDLTMFPPFSE |
| Interface Residues: | 91, 93, 94, 95, 97, 98, 101, 102, 128 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 4zpk_A, 6g1l_A, 5gnj_I, 7xi3_A, 5sy7_B, 4zpk_B, 7d8t_A, 5i50_B, 4h10_A, 5v0l_A, 4zpr_B, 7ssa_L, 4h10_B, 8osl_O, 5eyo_A, 1am9_A, 5nj8_D, 8osl_P, 5nj8_C, 7xhv_B, 7xi3_B, 5v0l_B |
| Binding Motifs: | ARNT_MOUSE.H10MO.B|M01013 tyrCGTGc MA0004.1 CACGTG MA0006.1 yGCGTG MA0006.2 GCGTG |
| Binding Sites: | MA0006.2.9 MA0004.1.1 MA0004.1.10 MA0004.1.11 MA0004.1.12 MA0004.1.13 MA0004.1.14 MA0004.1.15 MA0004.1.16 MA0004.1.17 MA0004.1.18 MA0004.1.19 MA0004.1.2 MA0004.1.20 / MA0006.1.5 MA0004.1.3 MA0004.1.4 MA0004.1.5 MA0004.1.6 MA0004.1.7 MA0004.1.8 MA0004.1.9 MA0006.1.1 MA0006.1.10 MA0006.1.11 MA0006.1.12 MA0006.1.13 MA0006.1.14 MA0006.1.15 MA0006.1.16 MA0006.1.17 MA0006.1.18 MA0006.1.19 MA0006.1.2 MA0006.1.20 MA0006.1.3 MA0006.1.4 MA0006.1.6 MA0006.1.7 MA0006.1.8 MA0006.1.9 MA0006.2.1 MA0006.2.10 MA0006.2.11 MA0006.2.12 MA0006.2.13 MA0006.2.14 MA0006.2.15 MA0006.2.16 MA0006.2.17 MA0006.2.18 MA0006.2.19 MA0006.2.2 MA0006.2.20 MA0006.2.3 MA0006.2.4 MA0006.2.5 MA0006.2.6 MA0006.2.7 MA0006.2.8 |
| Publications: | Swanson H. I., Chan W. K., Bradfield C. A. DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J. Biol. Chem. 270:26292-26302 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.