Transcription Factor
| Accessions: | P09086 (JASPAR 2024) |
| Names: | Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, PO2F2_HUMAN, POU domain, class 2, transcription factor 2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 479 |
| Pfam Domains: | 196-269 Pou domain - N-terminal to homeobox domain 298-354 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS 60 61 TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL 120 121 QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS 180 181 HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT 240 241 ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK 300 301 RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA 360 361 APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG 420 421 GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP |
| Interface Residues: | 221, 237, 238, 239, 240, 242, 243, 249, 253, 298, 299, 300, 301, 339, 340, 342, 343, 346, 347, 350, 351, 354, 384 |
| 3D-footprint Homologues: | 7u0g_M, 3l1p_A, 3d1n_M, 2xsd_C, 1e3o_C, 1au7_A, 7xrc_C, 8g87_X, 1o4x_A, 4cyc_A, 1puf_A, 1fjl_B, 3cmy_A, 2h1k_B, 1ig7_A, 5zjt_E, 1jgg_B, 1zq3_P, 3lnq_A, 2lkx_A, 1nk2_P, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 3a01_E, 1b72_A, 7psx_B, 4xrs_G, 3rkq_B, 2r5y_A, 5jlw_D, 1le8_A, 5hod_A, 6fqp_B, 4qtr_D, 1du0_A, 5flv_I |
| Binding Motifs: | MA0507.1 ykmATTTGCATrw MA0507.2 awTATGCAAATkAg MA0507.3 wTATGCAAATkAg |
| Binding Sites: | MA0507.1.1 MA0507.1.10 MA0507.1.11 MA0507.1.12 MA0507.1.13 MA0507.1.14 / MA0507.1.6 / MA0507.1.9 MA0507.1.15 MA0507.1.16 MA0507.1.17 MA0507.1.18 MA0507.1.19 MA0507.1.2 MA0507.1.20 MA0507.1.3 MA0507.1.4 MA0507.1.5 MA0507.1.7 MA0507.1.8 |
| Publications: | Shore P, Dietrich W, Corcoran L.M. Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. Nucleic acids research 30:1767-73 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.