Transcription Factor
| Accessions: | UP00585B (UniPROBE 20160601) |
| Names: | B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL5, BCL6_H676Y, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, ZNF51 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | B-cell lymphoma 6 protein: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing th |
| Length: | 193 |
| Pfam Domains: | 29-53 Zinc-finger double domain 42-65 C2H2-type zinc finger 43-65 C2H2-type zinc finger 43-65 Zinc finger, C2H2 type 57-81 Zinc-finger double domain 71-91 Zinc-finger of C2H2 type 71-90 C2H2-type zinc finger 71-93 Zinc finger, C2H2 type 71-82 C2H2-type zinc finger 85-109 Zinc-finger double domain 98-109 C2H2-type zinc finger 99-121 Zinc finger, C2H2 type 99-121 C2H2-type zinc finger 113-138 Zinc-finger double domain 127-149 Zinc finger, C2H2 type 127-146 C2H2-type zinc finger 127-149 C2H2-type zinc finger 129-148 Zinc-finger of C2H2 type 142-165 Zinc-finger double domain 155-171 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 TQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLAS 60 61 HKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLI 120 121 HTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLYLRQKHGA 180 181 ITNTKVQYRVSAT |
| Interface Residues: | 26, 28, 29, 32, 53, 54, 55, 56, 57, 59, 60, 62, 63, 64, 66, 71, 81, 82, 83, 84, 85, 87, 88, 89, 91, 92, 109, 110, 111, 112, 113, 114, 115, 116, 117, 137, 138, 139, 140, 141, 142, 143, 144, 145, 147, 148, 165, 166, 167, 168, 169, 171, 172 |
| 3D-footprint Homologues: | 5k5l_F, 1tf6_A, 5v3j_F, 6wmi_A, 7w1m_H, 5yel_A, 1ubd_C, 8cuc_F, 7n5w_A, 2gli_A, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 1mey_C, 5kl3_A, 8ssq_A, 7eyi_G, 8h9h_G, 2i13_A, 7ysf_A, 2jpa_A, 2kmk_A, 6jnm_A, 1tf3_A, 5und_A, 1g2f_F, 4x9j_A, 1llm_D, 6blw_A, 6u9q_A, 5ei9_F, 5k5i_A, 4m9v_C, 2lt7_A, 7y3m_I, 6e94_A, 7y3l_A, 7txc_E, 2drp_D, 1f2i_J, 5yj3_D, 6a57_A, 3uk3_C, 2wbs_A |
| Binding Motifs: | UP00585B_1 wywmtskkyTAATTAhmmkrkda |
| Binding Sites: | AACAATTA AATTAATA AATTAATG ACAATTAT ACCAATTA ACTAATTA ATAATTAC ATTAATGA ATTAATTA CAATTAAG CCAATTAA CTAATTAA CTAATTAG GCTAATTA GTAATTAA GTTAATTA TAATTATA TTAATTAA AATTAGTA AATTAGTC |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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