Transcription Factor

Accessions: T093341_1.02 (CISBP 1.02), Q05925 (JASPAR 2024)
Names: EN1, T093341_1.02;, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed-1, Hu-En-1
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: family:Homeodomain
Length: 392
Pfam Domains: 304-360 Homeobox domain
361-392 Engrailed homeobox C-terminal signature domain
Sequence:
(in bold interface residues)
1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPP 60
61 AAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKE 120
121 QPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPP 180
181 DGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGT 240
241 KYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNE 300
301 KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360
361 ATGIKNGLALHLMAQGLYNHSTTTVQDKDESE
Interface Residues: 291, 304, 305, 306, 307, 345, 346, 348, 349, 352, 353, 356, 357, 360
3D-footprint Homologues: 5zfz_A, 1ig7_A, 6fqp_B, 1puf_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 6m3d_C, 1zq3_P, 2ld5_A, 2hos_A, 7psx_B, 4j19_B, 2d5v_B, 5flv_I, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 3rkq_B, 1puf_B, 1au7_A, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 6fqq_E, 1k61_B, 4xrm_B, 8g87_X
Binding Motifs: MA0027.2 syAATTAg
M3191_1.02 RTarTkg
MA0027.3 yAATTA
Publications: Catron K. M., Iller N., Abate C. Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins. Mol. Cell. Biol. 13:2354-2365 (1993). [Pubmed]
Related annotations: PaperBLAST

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