Transcription Factor
Accessions: | T093341_1.02 (CISBP 1.02), Q05925 (JASPAR 2024) |
Names: | EN1, T093341_1.02;, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed-1, Hu-En-1 |
Organisms: | Homo sapiens |
Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Notes: | family:Homeodomain |
Length: | 392 |
Pfam Domains: | 304-360 Homeobox domain 361-392 Engrailed homeobox C-terminal signature domain |
Sequence: (in bold interface residues) | 1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPP 60 61 AAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKE 120 121 QPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPP 180 181 DGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGT 240 241 KYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNE 300 301 KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360 361 ATGIKNGLALHLMAQGLYNHSTTTVQDKDESE |
Interface Residues: | 291, 304, 305, 306, 307, 345, 346, 348, 349, 352, 353, 356, 357, 360 |
3D-footprint Homologues: | 5zfz_A, 1ig7_A, 6fqp_B, 1puf_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 3lnq_A, 1jgg_B, 2lkx_A, 1nk2_P, 6m3d_C, 1zq3_P, 2ld5_A, 2hos_A, 7psx_B, 4j19_B, 2d5v_B, 5flv_I, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 3rkq_B, 1puf_B, 1au7_A, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2xsd_C, 1e3o_C, 7xrc_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 6fqq_E, 1k61_B, 4xrm_B, 8g87_X |
Binding Motifs: | MA0027.2 syAATTAg M3191_1.02 RTarTkg MA0027.3 yAATTA |
Publications: | Catron K. M., Iller N., Abate C. Nucleotides flanking a conserved TAAT core dictate the DNA binding specifity of three murine homeodomain proteins. Mol. Cell. Biol. 13:2354-2365 (1993). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.