Transcription Factor

Accessions: BHLHE41 (HT-SELEX2 May2017)
Names: BHLHE41, ENSG00000123095
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2
Length: 122
Pfam Domains: 26-76 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 YSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHL 60
61 EKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVL 120
121 QY
Interface Residues: 26, 27, 29, 30, 33, 34, 60
3D-footprint Homologues: 5v0l_A, 7f2f_B, 1am9_A, 7xi3_A, 4zpk_A, 7rcu_E, 5nj8_D, 6g1l_A, 7ssa_L, 4h10_A, 7d8t_A, 5eyo_A, 1a0a_B, 8osl_P, 1an4_A, 4h10_B, 8osl_O, 7xhv_B, 5nj8_C, 4zpr_B, 5sy7_B, 5v0l_B, 7xi3_B
Binding Motifs: BHLHE41_2 gTCACGTGAc
BHLHE41_methyl_1 rTCACGTGAy
Related annotations: PaperBLAST

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