Transcription Factor
| Accessions: | SMAD4_HUMAN (HOCOMOCO 10), Q13485 (JASPAR 2024) |
| Names: | Deletion target in pancreatic carcinoma 4, hSMAD4, MAD homolog 4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4, SMAD4_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 552 |
| Pfam Domains: | 37-137 MH1 domain 319-531 MH2 domain |
| Sequence: (in bold interface residues) | 1 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA 60 61 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD 120 121 LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ 180 181 TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI 240 241 ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH 300 301 YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD 360 361 RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR 420 421 APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP 480 481 AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL 540 541 HTMPIADPQPLD |
| Interface Residues: | 79, 81, 83, 88, 354, 361 |
| 3D-footprint Homologues: | 6fzs_A, 6h3r_A, 5nm9_A, 5od6_A, 5mey_A, 5j0n_F |
| Binding Motifs: | MA0513.1 ctGTCTskCACct SMAD4_HUMAN.H10MO.C|M01504 swGTCTgkCACct |
| Binding Sites: | MA0513.1.1 MA0513.1.10 MA0513.1.11 MA0513.1.12 MA0513.1.13 MA0513.1.14 MA0513.1.15 MA0513.1.16 MA0513.1.17 MA0513.1.18 MA0513.1.19 MA0513.1.2 MA0513.1.20 MA0513.1.3 MA0513.1.4 MA0513.1.5 MA0513.1.6 MA0513.1.7 MA0513.1.8 MA0513.1.9 |
| Publications: | Shi Y., Wang Y. F., Jayaraman L., Yang H., Massague J., Pavletich N. P. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 94:585-594 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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