Transcription Factor

						

			
Accessions: P48996 (JASPAR 2024)

			
Names: Chromosome condensation protein dpy-27, DPY27_CAEEL, Protein dumpy-27
Organisms: Caenorhabditis elegans
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P48996
Length: 1469
Pfam Domains:    93-529 RecF/RecN/SMC N terminal domain
  117-148 AAA domain
  621-736 SMC proteins Flexible Hinge Domain
 835-1328 RecF/RecN/SMC N terminal domain
Sequence: 
(in bold interface residues)		   1 MQPFKRRALTSDDDRPYADTDSMPEVDLDVDRRRQYMEQLNIFDDVSSGAYMLELEAAEN   60
  61 GVKYDEKEDLLNVQIPPKYEDQISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMI  120
 121 LGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINSGGNYESCSVTIMFQMVKDMPVEN  180
 181 YDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQELLLRAGIDMTHNRFLILQGE  240
 241 VEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVSLLEHKSSQYGASVRRH  300
 301 EGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAETMRDAKMSLVTRTGELEEN  360
 361 KDIMLEAKDEVRKKETHERSLNSIVTELENKRIDWQSKKNDWHARDAKRKQGLKSCTQDL  420
 421 GKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQENVCQRTATENLIKYDQKS  480
 481 SADRAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELKGTLQTMM  540
 541 AENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQE  600
 601 VTYRHQATAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDEC  660
 661 RIGIGFCHEYKLPRTTFVFLDHLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFL  720
 721 IHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMS  780
 781 GVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEEIRADNGPIIKQLEIRKRELIMSTKEQK  840
 841 TRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYK  900
 901 RKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQTAIIENNPSHLEQAEKKLSELEHMC  960
 961 LEKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTT 1020
1021 VDNYNMVKQTYDELMRIIDDLENKTMADNAELDIIESAWMQPEKLYPPGKFVRYNDPDIA 1080
1081 AKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLEKDVDKFRREFD 1140
1141 NKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQML 1200
1201 YQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFA 1260
1261 MHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLG 1320
1321 IYKIDGKTYNIMVDPIAVEIKNRPILKIFEEEIKRREKLRRAEIEPEIDLSNGLSNVVIA 1380
1381 PKRKQRRLEMLKLSDFGLDDDSDLPEFNRFPPATRRELSVEDSDEDDEPVRRRPRRQVEE 1440
1441 EDEEDELIEEATPSPPPIVVQRRVRRSRH
Interface Residues: 159, 201, 1254
3D-footprint Homologues: 5f3w_B, 5dny_B, 2iie_A
Binding Motifs: MA0540.1 ysTCCCTkCGCgWwdr
Binding Sites: MA0540.1.1
MA0540.1.10
MA0540.1.11
MA0540.1.12
MA0540.1.13
MA0540.1.14
MA0540.1.15
MA0540.1.16
MA0540.1.17
MA0540.1.18
MA0540.1.19
MA0540.1.2
MA0540.1.20
MA0540.1.3
MA0540.1.4
MA0540.1.5
MA0540.1.6
MA0540.1.7
MA0540.1.8
MA0540.1.9
			
Publications: Ercan S, Giresi P.G, Whittle C.M, Zhang X, Green R.D, Lieb J.D. X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation. Nature genetics 39:403-8 (2007). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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