Transcription Factor
| Accessions: | ARX_DBD (HumanTF 1.0), ARX (HT-SELEX2 May2017) |
| Names: | Aristaless-related homeobox, ARX, ARX_HUMAN, Homeobox protein ARX, ENSG00000004848 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q96QS3 |
| Notes: | Ensembl ID: ENSG00000004848; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 129 |
| Pfam Domains: | 40-96 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQK 60 61 THYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHP 120 121 LSPYLDASP |
| Interface Residues: | 40, 41, 42, 43, 81, 82, 84, 85, 88, 89, 92, 93, 95, 96 |
| 3D-footprint Homologues: | 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | ARX_DBD hTAATywrATTAa ARX_2 ctAATTAa ARX_methyl_1 yyAATTAm |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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