Transcription Factor
| Accessions: | NFYA_HUMAN (HOCOMOCO 10), P23511 (JASPAR 2024) |
| Names: | CAAT box DNA-binding protein subunit A, NF-YA, NFYA_HUMAN, Nuclear transcription factor Y subunit alpha |
| Organisms: | Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 347 |
| Pfam Domains: | 262-318 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B |
| Sequence: (in bold interface residues) | 1 MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPL 60 61 MVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAV 120 121 QVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTIL 180 181 QQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMV 240 241 PGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLH 300 301 ESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS |
| Interface Residues: | 146, 155, 156, 157, 158, 160, 161, 303, 306, 310, 312, 317, 318 |
| 3D-footprint Homologues: | 6cro_A, 6r2v_A, 4awl_A, 4g92_A |
| Binding Motifs: | MA0060.2 agmsykCTGATTGGyysr NFYA_HUMAN.H10MO.A|M01368 yrrCCAATsrgmr MA0060.1 myyrrCCAATsrgmrs MA0060.3 rrCCAATCAgm MA0060.4 CCAATCAg |
| Binding Sites: | MA0060.4.17 MA0060.4.12 / MA0060.4.13 / MA0060.4.14 / MA0060.4.15 / MA0060.4.16 / MA0060.4.2 / MA0060.4.20 / MA0060.4.6 / MA0060.4.8 MA0060.1.1 MA0060.1.10 MA0060.1.11 MA0060.1.12 MA0060.1.13 MA0060.1.14 MA0060.1.15 MA0060.1.16 MA0060.1.17 MA0060.1.18 MA0060.1.19 MA0060.1.2 MA0060.1.20 MA0060.1.3 MA0060.1.4 MA0060.1.5 MA0060.1.6 MA0060.1.7 MA0060.1.8 MA0060.1.9 MA0060.2.1 MA0060.2.10 MA0060.2.11 MA0060.2.12 MA0060.2.13 MA0060.2.14 / MA0060.2.17 / MA0060.2.19 MA0060.2.15 MA0060.2.16 MA0060.2.18 / MA0060.2.6 MA0060.2.2 MA0060.2.20 MA0060.2.3 / MA0060.2.7 / MA0060.2.9 MA0060.2.4 MA0060.2.5 MA0060.2.8 MA0060.3.1 MA0060.3.10 MA0060.3.11 MA0060.3.12 MA0060.3.13 MA0060.3.14 MA0060.3.15 MA0060.3.16 MA0060.3.17 MA0060.3.18 MA0060.3.19 / MA0060.3.2 MA0060.3.20 MA0060.3.3 MA0060.3.4 MA0060.3.5 MA0060.3.6 MA0060.3.7 MA0060.3.8 MA0060.3.9 MA0060.4.1 MA0060.4.10 MA0060.4.11 MA0060.4.18 / MA0060.4.5 MA0060.4.19 MA0060.4.3 MA0060.4.4 MA0060.4.7 MA0060.4.9 |
| Publications: | Mantovani R. A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res. 26:1135-1143 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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