Transcription Factor

Accessions: ELK3_DBD (HumanTF 1.0), ELK3_TF2 (HumanTF2 1.0)
Names: ELK3, ELK3_HUMAN, ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, SAP-2, Serum response factor accessory protein 2, SRF accessory protein 2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P41970
Notes: Ensembl ID: ENSG00000111145; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000111145; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 109
Pfam Domains: 5-86 Ets-domain
Sequence:
(in bold interface residues)
1 MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLS 60
61 RALRYYYDKNIIKKVIGQKFVYKFVSFPEILKMDPHAVEISRESLLLQD
Interface Residues: 57, 58, 60, 61, 62, 64, 65, 79
3D-footprint Homologues: 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: ELK3_DBD aCCGGAAGTr
FOXO1_ELK3_1 rcCGGAwGTkkw
FOXO1_ELK3_2 rwmAACAGGAAGtr
GCM1_ELK3_1 aCCCGCArCCGGAAGy
GCM1_ELK3_2 rTGCGGGCGGAAGtg
HOXB2_ELK3_1 aCCGGAAGTmrTtA
HOXB2_ELK3_2 TrAygkgwacCGGAAGTr
HOXD12_ELK3_1 kTTwAykRCCGGAAgtd
HOXD12_ELK3_2 avCGGAAGTrrTwAAr
HOXD12_ELK3_2_3 ksCGGAAGThRTwAwa
TEAD4_ELK3 ACCGGAAGTdawmrMATwCy
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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