Transcription Factor

Accessions: Q9NYD6 (JASPAR 2024)
Names: Homeobox protein Hox-3I, Homeobox protein Hox-C10, HXC10_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9NYD6
Length: 342
Pfam Domains: 269-325 Homeobox domain
Sequence:
(in bold interface residues)
1 MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGS 60
61 SPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRA 120
121 KSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASL 180
181 NPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADS 240
241 SPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLE 300
301 ISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSNFNFT
Interface Residues: 269, 270, 271, 272, 310, 311, 313, 314, 317, 318, 321, 322, 325
3D-footprint Homologues: 6a8r_A, 1fjl_B, 2h1k_B, 5zfz_A, 1puf_A, 1ig7_A, 6m3d_C, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 2hos_A, 5jlw_D, 4xrs_G, 3a01_E, 1b72_A, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 1jgg_B, 7psx_B, 1e3o_C, 2xsd_C, 1au7_A, 1le8_A, 7xrc_C, 4qtr_D, 1k61_B, 1o4x_A, 1mnm_C, 1du0_A, 5hod_A
Binding Motifs: MA0905.1 rTCrTwAAaw
MA0905.2 rTCrTwAAa
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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