Transcription Factor
| Accessions: | ZNF382 (humanC2H2ZF-ChIP Feb2015), Q96SR6 (JASPAR 2024) |
| Names: | ENSG00000161298, Q96SR6, ZNF382, KRAB/zinc finger suppressor protein 1, KS1, Multiple zinc finger and krueppel-associated box protein KS1, Zinc finger protein 382, ZN382_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 550 |
| Pfam Domains: | 7-47 KRAB box 296-318 Zinc finger, C2H2 type 296-318 C2H2-type zinc finger 296-316 C2H2-type zinc finger 312-334 Zinc-finger double domain 324-346 Zinc finger, C2H2 type 324-346 C2H2-type zinc finger 324-334 C2H2-type zinc finger 338-362 Zinc-finger double domain 352-374 Zinc finger, C2H2 type 352-374 C2H2-type zinc finger 367-389 Zinc-finger double domain 380-402 C2H2-type zinc finger 380-402 C2H2-type zinc finger 380-402 Zinc finger, C2H2 type 398-417 Zinc-finger double domain 408-430 C2H2-type zinc finger 408-423 C2H2-type zinc finger 408-430 Zinc finger, C2H2 type 423-445 Zinc-finger double domain 436-458 Zinc finger, C2H2 type 436-458 C2H2-type zinc finger 436-445 C2H2-type zinc finger 451-474 Zinc-finger double domain 464-486 Zinc finger, C2H2 type 464-482 C2H2-type zinc finger 464-474 C2H2-type zinc finger 479-503 Zinc-finger double domain 494-514 Zinc finger, C2H2 type 494-514 C2H2-type zinc finger 494-514 C2H2-type zinc finger 506-531 Zinc-finger double domain 519-542 C2H2-type zinc finger 520-542 Zinc finger, C2H2 type 520-542 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MPLQGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFVSVGFHMAKPDMIRKLE 60 61 QGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLIFINHKKLIKERSNIYGKT 120 121 FTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEKFGDSTGWEKSLLNTKHEKIH 180 181 PAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGERTF 240 241 EYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPY 300 301 CGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKS 360 361 FRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQK 420 421 TTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILT 480 481 VHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVHQK 540 541 THKVETTGIQ |
| Interface Residues: | 306, 307, 309, 310, 313, 334, 335, 336, 337, 338, 341, 363, 364, 365, 366, 368, 369, 390, 391, 392, 393, 394, 396, 397, 399, 400, 403, 418, 419, 420, 421, 422, 424, 425, 436, 446, 447, 448, 449, 450, 451, 453, 456, 474, 475, 476, 477, 478, 479, 480, 481, 482, 487, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 513, 530, 531, 532, 533, 534, 537 |
| 3D-footprint Homologues: | 6jnm_A, 8ssq_A, 7w1m_H, 5k5l_F, 5v3j_F, 6a57_A, 8ssu_A, 2lt7_A, 7ysf_A, 5yel_A, 6blw_A, 5kkq_D, 5ei9_F, 6wmi_A, 1ubd_C, 7n5w_A, 3uk3_C, 1tf3_A, 2i13_A, 6u9q_A, 5und_A, 2gli_A, 1g2f_F, 1tf6_A, 4x9j_A, 8h9h_G, 7eyi_G, 2jpa_A, 1llm_D, 2wbs_A, 1mey_C, 5kl3_A, 5k5i_A, 6ml4_A, 7y3m_I, 6e94_A, 2kmk_A, 7txc_E, 8gn3_A, 4m9v_C, 8cuc_F, 7y3l_A, 2drp_D, 1f2i_J, 5yj3_D |
| Binding Motifs: | ZNF382_ChIP rrwaaTAACAaa MA1594.1 AgGrGAyATyACyACmGAyCCyAC |
| Binding Sites: | MA1594.1.1 / MA1594.1.3 MA1594.1.10 / MA1594.1.12 MA1594.1.11 / MA1594.1.13 MA1594.1.12 / MA1594.1.14 MA1594.1.13 / MA1594.1.15 MA1594.1.14 / MA1594.1.16 MA1594.1.15 / MA1594.1.17 MA1594.1.16 / MA1594.1.18 MA1594.1.17 MA1594.1.18 / MA1594.1.19 MA1594.1.19 / MA1594.1.20 MA1594.1.2 / MA1594.1.4 MA1594.1.20 MA1594.1.3 / MA1594.1.5 MA1594.1.4 / MA1594.1.6 MA1594.1.5 / MA1594.1.7 MA1594.1.6 / MA1594.1.8 MA1594.1.7 / MA1594.1.9 MA1594.1.10 / MA1594.1.8 MA1594.1.11 / MA1594.1.9 MA1594.1.1 MA1594.1.2 |
| Publications: | Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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