Transcription Factor

						

			
Accessions: Q15319 (JASPAR 2024)

			
Names: Brain-3C, Brain-specific homeobox/POU domain protein 3C, Brn-3C, PO4F3_HUMAN, POU domain, class 4, transcription factor 3
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q15319
Length: 338
Pfam Domains:   181-256 Pou domain - N-terminal to homeobox domain
  275-331 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEAL   60
  61 AAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLL  120
 121 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDV  180
 181 ESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNN  240
 241 MIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPS  300
 301 SEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
Interface Residues: 205, 206, 224, 225, 226, 227, 229, 230, 236, 240, 275, 276, 277, 278, 316, 317, 319, 320, 323, 324, 327, 328, 331
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 3cro_R, 8g87_X, 1au7_A, 2xsd_C, 1o4x_A, 1e3o_C, 7xrc_C, 1ig7_A, 6a8r_A, 1puf_A, 3cmy_A, 2h1k_B, 5zfz_A, 1fjl_B, 1nk2_P, 1zq3_P, 1jgg_B, 2lkx_A, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 5zjt_E, 3rkq_B, 5hod_A, 1b72_A, 3a01_E, 2r5y_A, 1puf_B, 7psx_B, 5flv_I, 2hdd_A, 5jlw_D, 1le8_A, 4qtr_D, 2d5v_B, 4xrs_G
Binding Motifs: MA0791.1 aTgmATwATTaATgag
MA0791.2 TgmATwATTaAT
			
Publications: Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135:271-80 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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