Transcription Factor

Accessions: T012351_1.02 (CISBP 1.02), Q9LNJ5 (JASPAR 2024)
Names: AT1G01260, T012351_1.02;, AtbHLH13, Basic helix-loop-helix protein 13, BH013_ARATH, bHLH 13, bHLH transcription factor bHLH013, Transcription factor bHLH13, Transcription factor EN 39
Organisms: Arabidopsis thaliana
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:bHLH
Length: 590
Pfam Domains: 48-236 bHLH-MYC and R2R3-MYB transcription factors N-terminal
433-478 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MNIGRLVWNEDDKAIVASLLGKRALDYLLSNSVSNANLLMTLGSDENLQNKLSDLVERPN 60
61 ASNFSWNYAIFWQISRSKAGDLVLCWGDGYCREPKEGEKSEIVRILSMGREEETHQTMRK 120
121 RVLQKLHDLFGGSEEENCALGLDRVTDTEMFLLSSMYFSFPRGEGGPGKCFASAKPVWLS 180
181 DVVNSGSDYCVRSFLAKSAGIQTVVLVPTDLGVVELGSTSCLPESEDSILSIRSLFTSSL 240
241 PPVRAVALPVTVAEKIDDNRTKIFGKDLHNSGFLQHHQHHQQQQQQPPQQQQHRQFREKL 300
301 TVRKMDDRAPKRLDAYPNNGNRFMFSNPGTNNNTLLSPTWVQPENYTRPINVKEVPSTDE 360
361 FKFLPLQQSSQRLLPPAQMQIDFSAASSRASENNSDGEGGGEWADAVGADESGNNRPRKR 420
421 GRRPANGRAEALNHVEAERQRREKLNQRFYALRSVVPNISKMDKASLLGDAVSYINELHA 480
481 KLKVMEAERERLGYSSNPPISLDSDINVQTSGEDVTVRINCPLESHPASRIFHAFEESKV 540
541 EVINSNLEVSQDTVLHTFVVKSEELTKEKLISALSREQTNSVQSRTSSGR
Interface Residues: 434, 435, 437, 438, 441, 442, 446, 462, 464
3D-footprint Homologues: 7xq5_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 7ssa_L, 5gnj_I, 6g1l_A, 4h10_A, 7xi3_A, 5i50_B, 7d8t_A, 4zpk_A, 8osl_P, 1an4_A
Binding Motifs: M0150_1.02 sCACGTGk
MA0958.1 rCACGTGC
Publications: Fernández-Calvo P, Chini A, Fernández-Barbero G, Chico J.M, Gimenez-Ibanez S, Geerinck J, Eeckhout D, Schweizer F, Godoy M, Franco-Zorrilla J.M, Pauwels L, Witters E, Puga M.I, Paz-Ares J, Goossens A, Reymond P, De Jaeger G, Solano R. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. The Plant cell 23:701-15 (2011). [Pubmed]
Related annotations: PaperBLAST

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