Transcription Factor
| Accessions: | Q15475 (JASPAR 2024) |
| Names: | Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 284 |
| Pfam Domains: | 131-180 Homeobox domain 145-178 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHR 60 61 GNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRT 120 121 IWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDR 180 181 AAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGH 240 241 ARSSNYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDLGS |
| Interface Residues: | 119, 128, 166, 167, 169, 170, 173, 174, 177, 178, 180, 181 |
| 3D-footprint Homologues: | 4xrs_G, 4j19_B, 5jlw_D, 2ld5_A, 7xrc_C, 1le8_A, 1ig7_A, 2xsd_C, 1e3o_C, 7q3o_C, 1au7_A, 1nk2_P, 6fqq_E, 1fjl_B, 5hod_A, 3rkq_B, 2r5y_A, 1zq3_P, 6a8r_A, 1b72_A, 4xrm_B, 3d1n_M, 1o4x_A, 4cyc_A, 2d5v_B, 8g87_X, 1le8_B, 6es3_K, 1du0_A, 3l1p_A, 1puf_A, 7psx_B, 1jgg_B, 5zfz_A, 3a01_E, 2h1k_B, 1mnm_C, 6fqp_B, 5flv_I, 3lnq_A, 2lkx_A, 1puf_B, 1k61_B, 5zjt_E, 4qtr_D, 3cmy_A, 2hdd_A, 2hos_A, 6m3d_C |
| Binding Motifs: | MA1118.1 GwAACCTGAkm MA1118.2 GwAACCTGA |
| Binding Sites: | MA1118.1.1 MA1118.1.10 MA1118.1.11 MA1118.1.12 MA1118.1.13 MA1118.1.14 MA1118.1.15 MA1118.1.16 MA1118.1.17 MA1118.1.18 MA1118.1.19 MA1118.1.2 MA1118.1.20 / MA1118.1.3 MA1118.1.4 MA1118.1.5 MA1118.1.6 MA1118.1.7 MA1118.1.8 MA1118.1.9 MA1118.2.1 MA1118.2.10 / MA1118.2.15 / MA1118.2.16 MA1118.2.11 / MA1118.2.13 MA1118.2.12 / MA1118.2.14 / MA1118.2.7 / MA1118.2.8 MA1118.2.17 / MA1118.2.18 / MA1118.2.6 MA1118.2.19 MA1118.2.2 MA1118.2.20 / MA1118.2.3 MA1118.2.4 MA1118.2.5 MA1118.2.9 |
| Publications: | Spitz F., Demignon J., Porteu A., Kahn A., Concordet J. P., Daegelen D., Maire P. Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.. Proc. Natl. Acad. Sci. USA 95:14220-14225 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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