Transcription Factor
Accessions: | BHLHE22_DBD (HumanTF 1.0), BHLHE22 (HT-SELEX2 May2017) |
Names: | BHE22_HUMAN, bHLHb5, BHLHE22, Class B basic helix-loop-helix protein 5, Class E basic helix-loop-helix protein 22, Trinucleotide repeat-containing gene 20 protein, ENSG00000180828 |
Organisms: | Homo sapiens |
Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
Uniprot: | Q8NFJ8 |
Notes: | Ensembl ID: ENSG00000180828; DNA-binding domain sequence; TF family: bHLH; Clone source: Megaman, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
Length: | 120 |
Pfam Domains: | 29-79 Helix-loop-helix DNA-binding domain |
Sequence: (in bold interface residues) | 1 GGGSGSGSGGSSSSSSSSSKKSKEQKALRLNINARERRRMHDLNDALDELRAVIPYAHSP 60 61 SVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALH 120 |
Interface Residues: | 29, 32, 33, 35, 36, 37, 39, 40 |
3D-footprint Homologues: | 2ypa_A, 6g1l_A, 7d8t_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D, 7z5k_B, 8osl_P, 4h10_A |
Binding Motifs: | BHLHE22_DBD aAmCATATGkTw BHLHE22_2 AmCATATGky BHLHE22_methyl_1 AmCATATGky |
Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.